Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy
DC Field | Value | Language |
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dc.contributor.author | Cao, T.G.N. | - |
dc.contributor.author | Kang, Ji Hee | - |
dc.contributor.author | Kim, Wangyu | - |
dc.contributor.author | Lim, Junha | - |
dc.contributor.author | Kang, Su Jin | - |
dc.contributor.author | You, Jae Young | - |
dc.contributor.author | Hoang, Q.T. | - |
dc.contributor.author | Kim, Won Jong | - |
dc.contributor.author | Rhee, Won Jong | - |
dc.contributor.author | Kim, Chulhong | - |
dc.contributor.author | Ko, Young Tag | - |
dc.contributor.author | Shim, Min Suk | - |
dc.date.accessioned | 2022-01-21T00:40:29Z | - |
dc.date.available | 2022-01-21T00:40:29Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 1838-7640 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83327 | - |
dc.description.abstract | Sonodynamic therapy has shown promise as an effective alternative to conventional photodynamic therapy owing to its ability to treat deep-seated tumors. However, the development of stimuli-responsive sonosensitizers with high biocompatibility faces a significant challenge. Methods: In this study, we developed dual stimuli-responsive sonosensitizers with desirable biosafety using extracellular vesicles (EVs), a class of naturally occurring nanoparticles. Indocyanine green (ICG), which functions as both a sonosensitizer and photoacoustic (PA) imaging agent, was loaded into EVs, together with paclitaxel (PTX) and sodium bicarbonate (SBC), to achieve pH-responsive PA imaging-guided chemo-sonodynamic combination therapy. Results: The EVs significantly improved the cellular uptake of ICG, thus triggering enhanced sonodynamic effects in breast cancer cells. SBC-, ICG-, and PTX-loaded EV [SBC-EV(ICG/PTX)] efficiently released the PTX in response to acidic pH in the endo/lysosomes because CO2 bubbles generated from the SBC caused the EV membranes to burst. The drug release was further facilitated by ultrasound (US) treatment, demonstrating dual pH/US-responsive drug release. The ICG- and PTX-loaded EVs exhibited efficient anticancer activity against breast tumor cells owing to the combination of chemo-sonodynamic therapy. High-resolution PA imaging visualized the preferential tumor accumulation of SBC-EV(ICG/PTX) in tumor-bearing mice. Notably, a single intravenous injection of SBC-EV(ICG/PTX) with US irradiation significantly suppressed tumor growth in mice without systemic toxicity. Conclusions: Our findings demonstrate that dual stimuli-responsive SBC-EV(ICG/PTX) are promising sonotheranostic nanoplatforms for safe and efficient chemo-sonodynamic combination cancer therapy and photoacoustic imaging. © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Ivyspring International Publisher | - |
dc.relation.isPartOf | Theranostics | - |
dc.title | Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000742478300001 | - |
dc.identifier.doi | 10.7150/thno.65516 | - |
dc.identifier.bibliographicCitation | Theranostics, v.12, no.3, pp.1247 - 1266 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85121922181 | - |
dc.citation.endPage | 1266 | - |
dc.citation.startPage | 1247 | - |
dc.citation.title | Theranostics | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kang, Ji Hee | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Extracellular vesicle | - |
dc.subject.keywordAuthor | PH-sensitive release | - |
dc.subject.keywordAuthor | Photoacoustic imaging | - |
dc.subject.keywordAuthor | Sonodynamic cancer therapy | - |
dc.subject.keywordAuthor | Sonotheranostics | - |
dc.subject.keywordPlus | INDOCYANINE-GREEN | - |
dc.subject.keywordPlus | DELIVERY VEHICLES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | FLUORESCENCE | - |
dc.subject.keywordPlus | STABILIZATION | - |
dc.subject.keywordPlus | PERSPECTIVES | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | STABILITY | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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