Octaphlorethol A, a marine algae product, exhibits antidiabetic effects in type 2 diabetic mice by activating AMP-activated protein kinase and upregulating the expression of glucose transporter 4
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung-Hong | - |
dc.contributor.author | Ko, Seok-Chun | - |
dc.contributor.author | Kang, Min-Cheol | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.date.available | 2020-02-28T02:41:32Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8338 | - |
dc.description.abstract | Octaphlorethol A (OPA), a type of phlorotannin isolated from Ishige foliacea has been shown to have antidiabetic activities. However, the mechanism of action of OPA in type 2 diabetes has not been investigated extensively. Here, we investigated the antidiabetic effects and mechanism of OPA in C57BL/KsJ-db/db mice, a model of type 2 diabetes. Levels of postprandial blood glucose were significantly lower in OPAtreated db/db mice than in control db/db mice. In addition, the OPA supplements significantly improved fasting blood glucose level and impaired glucose tolerance compared to control db/db mice. OPA also significantly decreased the level of serum insulin, augmented the activation of AMP-activated protein kinase (AMPK), and increased the expression of glucose transporter 4 (GLUT4) protein in skeletal muscle. In addition, it significantly suppressed the increases in hepatic mRNA expression level of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), gluconeogenesis-related enzymes. Therefore, the mechanisms of OPA may involve suppression of gluconeogenesis by inhibiting PEPCK and G6Pase activity in the liver and affecting GLUT4-mediated glucose uptake in skeletal muscle through activation of AMPK. These findings provide a new insight into the antidiabetic clinical applications of OPA and demonstrate the potential of OPA as a new drug candidate for type 2 diabetes. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.subject | C57BL/KSJ-DB/DB MICE | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | GLUCOSE-UPTAKE | - |
dc.subject | ECKLONIA-CAVA | - |
dc.subject | LIPID-METABOLISM | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | ETHANOL EXTRACT | - |
dc.subject | ISHIGE-FOLIACEA | - |
dc.subject | MOUSE MODEL | - |
dc.subject | BROWN ALGA | - |
dc.title | Octaphlorethol A, a marine algae product, exhibits antidiabetic effects in type 2 diabetic mice by activating AMP-activated protein kinase and upregulating the expression of glucose transporter 4 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000375629200006 | - |
dc.identifier.doi | 10.1016/j.fct.2016.02.022 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.91, pp.58 - 64 | - |
dc.identifier.scopusid | 2-s2.0-84960399657 | - |
dc.citation.endPage | 64 | - |
dc.citation.startPage | 58 | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 91 | - |
dc.contributor.affiliatedAuthor | Lee, Dae Ho | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Octaphlorethol A | - |
dc.subject.keywordAuthor | Type 2 diabetes | - |
dc.subject.keywordAuthor | AMP-activated protein kinase | - |
dc.subject.keywordAuthor | Glucose transporter 4 | - |
dc.subject.keywordAuthor | Phosphoenolpyruvate carboxykinase | - |
dc.subject.keywordAuthor | Glucose-6-phosphatase | - |
dc.subject.keywordPlus | C57BL/KSJ-DB/DB MICE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | GLUCOSE-UPTAKE | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | LIPID-METABOLISM | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | ETHANOL EXTRACT | - |
dc.subject.keywordPlus | ISHIGE-FOLIACEA | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | BROWN ALGA | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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