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Cited 39 time in webofscience Cited 47 time in scopus
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Octaphlorethol A, a marine algae product, exhibits antidiabetic effects in type 2 diabetic mice by activating AMP-activated protein kinase and upregulating the expression of glucose transporter 4

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dc.contributor.authorLee, Seung-Hong-
dc.contributor.authorKo, Seok-Chun-
dc.contributor.authorKang, Min-Cheol-
dc.contributor.authorLee, Dae Ho-
dc.contributor.authorJeon, You-Jin-
dc.date.available2020-02-28T02:41:32Z-
dc.date.created2020-02-06-
dc.date.issued2016-05-
dc.identifier.issn0278-6915-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8338-
dc.description.abstractOctaphlorethol A (OPA), a type of phlorotannin isolated from Ishige foliacea has been shown to have antidiabetic activities. However, the mechanism of action of OPA in type 2 diabetes has not been investigated extensively. Here, we investigated the antidiabetic effects and mechanism of OPA in C57BL/KsJ-db/db mice, a model of type 2 diabetes. Levels of postprandial blood glucose were significantly lower in OPAtreated db/db mice than in control db/db mice. In addition, the OPA supplements significantly improved fasting blood glucose level and impaired glucose tolerance compared to control db/db mice. OPA also significantly decreased the level of serum insulin, augmented the activation of AMP-activated protein kinase (AMPK), and increased the expression of glucose transporter 4 (GLUT4) protein in skeletal muscle. In addition, it significantly suppressed the increases in hepatic mRNA expression level of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), gluconeogenesis-related enzymes. Therefore, the mechanisms of OPA may involve suppression of gluconeogenesis by inhibiting PEPCK and G6Pase activity in the liver and affecting GLUT4-mediated glucose uptake in skeletal muscle through activation of AMPK. These findings provide a new insight into the antidiabetic clinical applications of OPA and demonstrate the potential of OPA as a new drug candidate for type 2 diabetes. (C) 2016 Elsevier Ltd. All rights reserved.-
dc.language영어-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.relation.isPartOfFOOD AND CHEMICAL TOXICOLOGY-
dc.subjectC57BL/KSJ-DB/DB MICE-
dc.subjectINSULIN-RESISTANCE-
dc.subjectGLUCOSE-UPTAKE-
dc.subjectECKLONIA-CAVA-
dc.subjectLIPID-METABOLISM-
dc.subjectSKELETAL-MUSCLE-
dc.subjectETHANOL EXTRACT-
dc.subjectISHIGE-FOLIACEA-
dc.subjectMOUSE MODEL-
dc.subjectBROWN ALGA-
dc.titleOctaphlorethol A, a marine algae product, exhibits antidiabetic effects in type 2 diabetic mice by activating AMP-activated protein kinase and upregulating the expression of glucose transporter 4-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000375629200006-
dc.identifier.doi10.1016/j.fct.2016.02.022-
dc.identifier.bibliographicCitationFOOD AND CHEMICAL TOXICOLOGY, v.91, pp.58 - 64-
dc.identifier.scopusid2-s2.0-84960399657-
dc.citation.endPage64-
dc.citation.startPage58-
dc.citation.titleFOOD AND CHEMICAL TOXICOLOGY-
dc.citation.volume91-
dc.contributor.affiliatedAuthorLee, Dae Ho-
dc.type.docTypeArticle-
dc.subject.keywordAuthorOctaphlorethol A-
dc.subject.keywordAuthorType 2 diabetes-
dc.subject.keywordAuthorAMP-activated protein kinase-
dc.subject.keywordAuthorGlucose transporter 4-
dc.subject.keywordAuthorPhosphoenolpyruvate carboxykinase-
dc.subject.keywordAuthorGlucose-6-phosphatase-
dc.subject.keywordPlusC57BL/KSJ-DB/DB MICE-
dc.subject.keywordPlusINSULIN-RESISTANCE-
dc.subject.keywordPlusGLUCOSE-UPTAKE-
dc.subject.keywordPlusECKLONIA-CAVA-
dc.subject.keywordPlusLIPID-METABOLISM-
dc.subject.keywordPlusSKELETAL-MUSCLE-
dc.subject.keywordPlusETHANOL EXTRACT-
dc.subject.keywordPlusISHIGE-FOLIACEA-
dc.subject.keywordPlusMOUSE MODEL-
dc.subject.keywordPlusBROWN ALGA-
dc.relation.journalResearchAreaFood Science & Technology-
dc.relation.journalResearchAreaToxicology-
dc.relation.journalWebOfScienceCategoryFood Science & Technology-
dc.relation.journalWebOfScienceCategoryToxicology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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