Use of Gemcitabine Plus Carboplatin Is Associated with Poor Outcomes in Urothelial Carcinoma Patients with Chronic Kidney Disease Stage 4-5
DC Field | Value | Language |
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dc.contributor.author | 김형돈 | - |
dc.contributor.author | 임현수 | - |
dc.contributor.author | 김좌훈 | - |
dc.contributor.author | 정혜현 | - |
dc.contributor.author | 윤신교 | - |
dc.contributor.author | 박인근 | - |
dc.contributor.author | 이재련 | - |
dc.date.accessioned | 2022-02-02T01:40:26Z | - |
dc.date.available | 2022-02-02T01:40:26Z | - |
dc.date.created | 2021-10-14 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83401 | - |
dc.description.abstract | Purpose This study aimed to investigate the clinical outcomes with gemcitabine-carboplatin (GCb), the standard treatment for patients with advanced urothelial carcinoma (UC) who are ineligible for cisplatin-based regimens, in advanced UC patients with a glomerular filtration rate (GFR) < 30 mL/min. Materials and Methods A retrospective cohort study involving GCb-treated advanced UC patients with GFR < 60 mL/min (n=89) was performed. Clinical outcomes were compared between subgroups with GFR < 30 mL/min and GFR ≥ 30 mL/min but < 60 mL/min. Results Most baseline characteristics were comparable between the two subgroups. Patients with GFR < 30 mL/min had a significantly lower objective response rate (12.5%) compared to those with higher GFR levels (56.7%) (p=0.004). The number of GCb cycles was significantly lower in patients with GFR < 30 mL/min (median 2 cycles) than in those with higher GFR levels (median 6 cycles) (p=0.002). Compared to those with GFR ≥ 30 mL/min but < 60 mL/min, patients with GFR < 30 mL/min showed significantly worse progression-free survival (PFS) and overall survival (OS) (p < 0.001 for both). Further stratification of patient subgroups according to their GFR (i.e., GFR ≥ 45 mL/min but < 60 mL/min vs. GFR ≥ 30 mL/min but < 45 mL/min vs. GFR < 30 mL/min) revealed significantly different PFS and OS (p < 0.001 for both). Conclusion The use of GCb is discouraged in advanced UC patients with GFR < 30 mL/min. Alternative therapeutic approaches with better efficacy are warranted for these patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한암학회 | - |
dc.relation.isPartOf | Cancer Research and Treatment | - |
dc.title | Use of Gemcitabine Plus Carboplatin Is Associated with Poor Outcomes in Urothelial Carcinoma Patients with Chronic Kidney Disease Stage 4-5 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000744519500007 | - |
dc.identifier.doi | 10.4143/crt.2021.091 | - |
dc.identifier.bibliographicCitation | Cancer Research and Treatment, v.53, no.4, pp.1166 - 1173 | - |
dc.identifier.kciid | ART002764977 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85118311556 | - |
dc.citation.endPage | 1173 | - |
dc.citation.startPage | 1166 | - |
dc.citation.title | Cancer Research and Treatment | - |
dc.citation.volume | 53 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | 박인근 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Urothelial carcinoma | - |
dc.subject.keywordAuthor | Gemcitabine plus carboplatin | - |
dc.subject.keywordAuthor | Glomerular filtration rate | - |
dc.subject.keywordAuthor | Objective response rate | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | METHOTREXATE | - |
dc.subject.keywordPlus | VINBLASTINE | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | UNFIT | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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