The current status and outcomes of in-hospital P2Y12 receptor inhibitor switching in Korean patients with acute myocardial infarction
DC Field | Value | Language |
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dc.contributor.author | Keun-Ho Park | - |
dc.contributor.author | Myung Ho Jeong | - |
dc.contributor.author | Hyun Kuk Kim | - |
dc.contributor.author | Young-Jae Ki | - |
dc.contributor.author | Sung Soo Kim | - |
dc.contributor.author | Youngkeun Ahn | - |
dc.contributor.author | Hyun Yi Kook | - |
dc.contributor.author | Hyo-Soo Kim | - |
dc.contributor.author | Hyeon-Cheol Gwon | - |
dc.contributor.author | Ki-Bae Seung | - |
dc.contributor.author | Seung Woon Rha | - |
dc.contributor.author | Shung Chull Chae | - |
dc.contributor.author | Chong Jin Kim | - |
dc.contributor.author | Kwang Soo Cha | - |
dc.contributor.author | Jong Seon Park | - |
dc.contributor.author | Junghan Yoon | - |
dc.contributor.author | Jei Keon Chae | - |
dc.contributor.author | Seung-Jae Joo | - |
dc.contributor.author | Dong-Joo Choi | - |
dc.contributor.author | Seung-Ho Hur | - |
dc.contributor.author | In-Whan Seong | - |
dc.contributor.author | Myeong Chan Cho | - |
dc.contributor.author | Doo Il Kim | - |
dc.contributor.author | Seok Kyu Oh | - |
dc.contributor.author | Tae Hoon Ahn | - |
dc.contributor.author | Jin-Yong Hwang | - |
dc.date.accessioned | 2022-03-01T03:40:30Z | - |
dc.date.available | 2022-03-01T03:40:30Z | - |
dc.date.created | 2022-02-25 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83594 | - |
dc.description.abstract | Background/Aims: While switching strategies of P2Y12 receptor inhibitors (RIs) have sometimes been used in acute myocardial infarction (AMI) patients, the current status of in-hospital P2Y12RI switching remains unknown. Methods: Overall, 8,476 AMI patients who underwent successful revascularization from Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) were divided according to in-hospital P2Y12RI strategies, and net adverse cardiovascular events (NACEs), defined as a composite of cardiac death, non-fatal myocardial infarction (MI), stroke, or thrombolysis in myocardial infarction (TIMI) major bleeding during hospitalization were compared. Results: Patients with in-hospital P2Y12RI switching accounted for 16.5%, of which 867 patients were switched from clopidogrel to potent P2Y12RI (C-P) and 532 patients from potent P2Y12RI to clopidogrel (P-C). There were no differences in NACEs among the unchanged clopidogrel, the unchanged potent P2Y12RIs, and the P2Y12RI switching groups. However, compared to the unchanged clopidogrel group, the C-P group had a higher incidence of non-fatal MI, and the P-C group had a higher incidence of TIMI major bleeding. In clinical events of in-hospital P2Y12RI switching, 90.9% of non-fatal MI occurred during pre-switching clopidogrel administration, 60.7% of TIMI major bleeding was related to pre-switching P2Y12RIs, and 71.4% of TIMI major bleeding was related to potent P2Y12RIs. Only 21.6% of the P2Y12RI switching group switched to P2Y12RIs after a loading dose (LD); however, there were no differences in clinical events between patients with and without LD. Conclusions: In-hospital P2Y12RI switching occurred occasionally, but had relatively similar clinical outcomes compared to unchanged P2Y12RIs in Korean AMI patients. Non-fatal MI and bleeding appeared to be mainly related to pre-switching P2Y12RIs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한내과학회 | - |
dc.relation.isPartOf | The Korean Journal of Internal Medicine | - |
dc.title | The current status and outcomes of in-hospital P2Y12 receptor inhibitor switching in Korean patients with acute myocardial infarction | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000755195200001 | - |
dc.identifier.doi | 10.3904/kjim.2021.101 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Internal Medicine, v.37, no.2, pp.350 - 365 | - |
dc.identifier.kciid | ART002811685 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85127490515 | - |
dc.citation.endPage | 365 | - |
dc.citation.startPage | 350 | - |
dc.citation.title | The Korean Journal of Internal Medicine | - |
dc.citation.volume | 37 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Tae Hoon Ahn | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.subject.keywordAuthor | Platelet aggregation inhibitors | - |
dc.subject.keywordAuthor | Hemorrhage | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | DE-ESCALATION | - |
dc.subject.keywordPlus | CLOPIDOGREL | - |
dc.subject.keywordPlus | PRASUGREL | - |
dc.subject.keywordPlus | TICAGRELOR | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | kci | - |
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