Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist
DC Field | Value | Language |
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dc.contributor.author | Sugawara, Reiko | - |
dc.contributor.author | Lee, Eun-Jung | - |
dc.contributor.author | Jang, Min Seong | - |
dc.contributor.author | Jeun, Eun-Ji | - |
dc.contributor.author | Hong, Chun-Pyo | - |
dc.contributor.author | Kim, Jung-Hwan | - |
dc.contributor.author | Park, Areum | - |
dc.contributor.author | Yun, Chang Ho | - |
dc.contributor.author | Hong, Sung-Wook | - |
dc.contributor.author | Kim, You-Me | - |
dc.contributor.author | Seoh, Ju-Young | - |
dc.contributor.author | Jung, YunJae | - |
dc.contributor.author | Surh, Charles D. | - |
dc.contributor.author | Miyasaka, Masayuki | - |
dc.contributor.author | Yang, Bo-Gie | - |
dc.contributor.author | Jang, Myoung Ho | - |
dc.date.available | 2020-02-28T02:42:15Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-04-04 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8370 | - |
dc.description.abstract | Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the Delta dblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4(+) T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1 beta. Moreover, small intestinal eosinophils isolated from IL-1Ra-deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.subject | COLONY-STIMULATING FACTOR | - |
dc.subject | T(H)17 CELLS | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | GM-CSF | - |
dc.subject | IMMUNE | - |
dc.subject | INFLAMMATION | - |
dc.subject | GENERATION | - |
dc.subject | IL-1-BETA | - |
dc.subject | INTERLEUKIN-23 | - |
dc.subject | MICROBIOTA | - |
dc.title | Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000373394100008 | - |
dc.identifier.doi | 10.1084/jem.20141388 | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL MEDICINE, v.213, no.4, pp.555 - 567 | - |
dc.identifier.scopusid | 2-s2.0-84995455338 | - |
dc.citation.endPage | 567 | - |
dc.citation.startPage | 555 | - |
dc.citation.title | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 213 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Jung, YunJae | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | T(H)17 CELLS | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | GM-CSF | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | IL-1-BETA | - |
dc.subject.keywordPlus | INTERLEUKIN-23 | - |
dc.subject.keywordPlus | MICROBIOTA | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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