Comprehensive Transcriptomic Analysis of Cordyceps militaris Cultivated on Germinated Soybeans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Chang-Hyuk | - |
dc.contributor.author | Abu Sadat, Md | - |
dc.contributor.author | Kim, Wonjae | - |
dc.contributor.author | Park, Tae-Sik | - |
dc.contributor.author | Park, Dong Ki | - |
dc.contributor.author | Choi, Jaehyuk | - |
dc.date.accessioned | 2022-03-18T02:40:49Z | - |
dc.date.available | 2022-03-18T02:40:49Z | - |
dc.date.created | 2022-03-16 | - |
dc.date.issued | 2022-01-02 | - |
dc.identifier.issn | 1229-8093 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83764 | - |
dc.description.abstract | The ascomycete fungus Cordyceps militaris infects lepidopteran larvae and pupae and forms characteristic fruiting bodies. Owing to its immune-enhancing effects, the fungus has been used as a medicine. For industrial application, this fungus can be grown on geminated soybeans as an alternative protein source. In our study, we performed a comprehensive transcriptomic analysis to identify core gene sets during C. militaris cultivation on germinated soybeans. RNA-Seq technology was applied to the fungal cultures at seven-time points (2, 4, and 7-day and 2, 3, 5, 7-week old cultures) to investigate the global transcriptomic change. We conducted a time-series analysis using a two-step regression strategy and chose 1460 significant genes and assigned them into five clusters. Characterization of each cluster based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases revealed that transcription profiles changed after two weeks of incubation. Gene mapping of cordycepin biosynthesis and isoflavone modification pathways also confirmed that gene expression in the early stage of GSC cultivation is important for these metabolic pathways. Our transcriptomic analysis and selected genes provided a comprehensive molecular basis for the cultivation of C. militaris on germinated soybeans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | MYCOBIOLOGY | - |
dc.title | Comprehensive Transcriptomic Analysis of Cordyceps militaris Cultivated on Germinated Soybeans | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000761226000001 | - |
dc.identifier.doi | 10.1080/12298093.2022.2035906 | - |
dc.identifier.bibliographicCitation | MYCOBIOLOGY, v.50, no.1, pp.1 - 11 | - |
dc.identifier.kciid | ART002820994 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85125716179 | - |
dc.citation.endPage | 11 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | MYCOBIOLOGY | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Park, Tae-Sik | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Cordyceps militaris | - |
dc.subject.keywordAuthor | RNA-seq | - |
dc.subject.keywordAuthor | germinated soybeans | - |
dc.subject.keywordAuthor | bioinformatics | - |
dc.subject.keywordPlus | ISOFLAVONES | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TIME | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Mycology | - |
dc.relation.journalWebOfScienceCategory | Agronomy | - |
dc.relation.journalWebOfScienceCategory | Mycology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.