Aucubin suppresses lipopolysaccharide-induced pro-inflammatory responses by blocking the NF-κB translocation signaling pathways in activated microglial cells
DC Field | Value | Language |
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dc.contributor.author | Park, Yong Joo | - |
dc.contributor.author | Lim, Ja Young | - |
dc.contributor.author | Kwon, Seung-Hwan | - |
dc.contributor.author | Shin, Myoung Sook | - |
dc.date.accessioned | 2022-03-27T07:40:07Z | - |
dc.date.available | 2022-03-27T07:40:07Z | - |
dc.date.created | 2022-02-25 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1874-3900 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83805 | - |
dc.description.abstract | Aucubin is an iridoid glycoside with demonstrable hepatoprotective and anti-osteoporotic effects. Herein, using microglial cells and lipopolysaccharide (LPS) to induce inflammatory responses, we studied the signaling pathways involved in the anti-inflammatory action of aucubin and their influence on the expression of several genes known to be involved in inflammation. Aucubin inhibited LPS-stimulated pro-inflammatory responses by suppressing the production of nitric oxide and prostaglandin E2. Furthermore, aucubin inhibited inducible nitric oxide synthase and cyclooxygenase-2 at both the protein and mRNA levels. In addition, aucubin inhibited pro-inflammatory cytokine production in LPS-stimulated BV-2 microglial cells. Subsequent mechanistic studies revealed that aucubin inhibited the LPS-induced activation of nuclear factor-kappa B (NF-κB) translocation and phosphorylation of phosphatidylinositol 3-kinases (PI3K)/Akt as well as of mitogen-activated protein kinases (MAPKs), which are upstream molecules responsible for controlling inflammatory reactions. These results suggest that aucubin may exert anti-neuroinflammatory responses by suppressing the LPS-induced expression of pro-inflammatory mediators by blocking the activation of NF-κB, PI3K/Akt, and MAPK signaling pathways in microglial cells. © 2022 Phytochemical Society of Europe | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | Phytochemistry Letters | - |
dc.title | Aucubin suppresses lipopolysaccharide-induced pro-inflammatory responses by blocking the NF-κB translocation signaling pathways in activated microglial cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000766608600022 | - |
dc.identifier.doi | 10.1016/j.phytol.2022.02.006 | - |
dc.identifier.bibliographicCitation | Phytochemistry Letters, v.48, pp.120 - 127 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85124813011 | - |
dc.citation.endPage | 127 | - |
dc.citation.startPage | 120 | - |
dc.citation.title | Phytochemistry Letters | - |
dc.citation.volume | 48 | - |
dc.contributor.affiliatedAuthor | Shin, Myoung Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Aucubin | - |
dc.subject.keywordAuthor | Lipopolysaccharide | - |
dc.subject.keywordAuthor | Microglial cells | - |
dc.subject.keywordAuthor | Nuclear factor-kappa B | - |
dc.subject.keywordAuthor | Pro-inflammatory responses | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | PROINFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY ACTIVITY | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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