Improvement of Damage in Human Dermal Fibroblasts by 3,5,7-Trimethoxyflavone from Black Ginger (Kaempferia parviflora)
DC Field | Value | Language |
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dc.contributor.author | Lee, Sullim | - |
dc.contributor.author | Jang, Taesu | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2022-03-27T07:40:14Z | - |
dc.date.available | 2022-03-27T07:40:14Z | - |
dc.date.created | 2022-02-27 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83814 | - |
dc.description.abstract | Reactive oxygen species (ROS) are generated during intrinsic (chronological aging) and extrinsic (photoaging) skin aging. Therefore, antioxidants that inhibit ROS production may be in-volved in delaying skin aging. In this study, we investigated the potential effects of compounds isolated from black ginger, Kaempferia parviflora, a traditional medicinal plant, on normal human dermal fibroblasts in the context of inflammation and oxidative stress. The isolated compounds were structurally characterized as 5-hydroxy-7-methoxyflavone (1), 3,7-dimethoxy-5-hydroxyflavone (2), 5-hydroxy-3,7,3,4-tetramethoxyflavone (3), 7,4-dimethylapigenin (4), 3,7,4-trimethylkaempferol (5), and 3,5,7-trimethoxyflavone (6), using nuclear magnetic resonance spectroscopy (NMR) and liquid chromatography–mass spectrometry (LC/MS) analyses. These flavonoids were first evaluated for their ability to suppress extracellular matrix degradation in normal human dermal fibroblasts. Of these, 3,5,7-trimethoxyflavone (6) significantly inhibited the tumor necrosis factor (TNF)-α-induced high expression and secretion of matrix metalloproteinase (MMP)-1 by cells. We further found that 3,5,7-trimethoxyflavone suppressed the excessive increase in ROS, mitogen-activated protein kinases (MAPKs), Akt, and cyclooxygenase-2 (COX-2)and increased heme oxygenase (HO)-1 expres-sion. The expression of pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and IL-8, was also suppressed by 3,5,7-trimethoxyflavone (6). Taken together, our results indicate that 3,5,7-trimethoxyflavone (6) isolated from K. parviflora is a potential candidate for ameliorating skin damage. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Antioxidants | - |
dc.title | Improvement of Damage in Human Dermal Fibroblasts by 3,5,7-Trimethoxyflavone from Black Ginger (Kaempferia parviflora) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000764351100001 | - |
dc.identifier.doi | 10.3390/antiox11020425 | - |
dc.identifier.bibliographicCitation | Antioxidants, v.11, no.2 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85124956229 | - |
dc.citation.title | Antioxidants | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Lee, Sullim | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 3,5,7-trimethoxyflavone | - |
dc.subject.keywordAuthor | Human dermal fibroblasts | - |
dc.subject.keywordAuthor | Improvement of skin damage | - |
dc.subject.keywordAuthor | Kaempferia parviflora | - |
dc.subject.keywordAuthor | Tumor necrosis factor-α | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | COLLAGENASE | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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