Amelioration of cancer cachexia with preemptive administration of tumor necrosis factor-alpha blocker
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Eun A. | - |
dc.contributor.author | Park, Jong Min | - |
dc.contributor.author | Jin, Wook | - |
dc.contributor.author | Tchahc, Hann | - |
dc.contributor.author | Kwon, Kwang An | - |
dc.contributor.author | Hahm, Ki Baik | - |
dc.date.accessioned | 2022-04-12T06:40:08Z | - |
dc.date.available | 2022-04-12T06:40:08Z | - |
dc.date.created | 2022-04-06 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 0912-0009 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83924 | - |
dc.description.abstract | Cancer cachexia is syndrome accompanying weight reduction, fat loss, muscle atrophy in patients with advanced cancer. Since tumor necrosis factor-alpha (TNF-alpha) played pivotal role in cancer cachexia, we hypothesized preemptive administration of TNF-alpha antibody might mitigate cancer cachexia. Detailed molecular mechanisms targeting muscle atrophy, cachexic inflammation, and catabolic catastrophe were explored whether TNF-alpha antibody can antagonize these cachexic mechanisms. Stimulated with preliminary finding human antibody, infliximab or adalimumab, significantly inhibited TNF-alpha as well as their signals relevant to cachexia in mice, preemptive administration of 1.5 mg/kg adalimumab was done in C-26-induced cancer cachexia. Adalimumab significantly mitigated cancer cachexia manifested with significantly lesser weight loss, leg muscle preservation, and higher survival compared to cachexia control (p<0.05). Significant ameliorating action of muscle atrophy were accompanied significant decreases of muscle-specific UPS like atrogin-1/MuRF-1, Pax-7, PCG-1 alpha, and Mfn-2 after adalimumab (p<0.01) and significantly attenuated lipolysis with inhibition of ATGL HSL, and MMPs. Cachexic factors including IL-6 expression, serum IL-6, gp130, IL-6R, JAK2, and STAT3 were significantly inhibited with adalimumab (p<0.01). Genes implicated in cachexic inflammation like NF-kappa B, c-Jun/c-Fos, and MAPKs were significantly repressed, while mTOR/AKT was significantly increased adalimumab (p<0.05). Conclusively, preemptive administration of adalimumab can be tried in high risk to cancer cachexia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | - |
dc.title | Amelioration of cancer cachexia with preemptive administration of tumor necrosis factor-alpha blocker | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000763105900005 | - |
dc.identifier.doi | 10.3164/jcbn.21-21 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, v.70, no.2, pp.117 - 128 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85126786556 | - |
dc.citation.endPage | 128 | - |
dc.citation.startPage | 117 | - |
dc.citation.title | JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | - |
dc.citation.volume | 70 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Jin, Wook | - |
dc.contributor.affiliatedAuthor | Tchahc, Hann | - |
dc.contributor.affiliatedAuthor | Kwon, Kwang An | - |
dc.contributor.affiliatedAuthor | Hahm, Ki Baik | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | cancer cachexia | - |
dc.subject.keywordAuthor | C-26 cell | - |
dc.subject.keywordAuthor | adalimumab | - |
dc.subject.keywordAuthor | muscle atrophy | - |
dc.subject.keywordAuthor | preemptive administration | - |
dc.subject.keywordPlus | E3 UBIQUITIN-LIGASES | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | MOLECULAR ANALYSIS | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | INCREASES | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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