진달래 뿌리 추출물의 알레르기 염증 억제 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장시성 | - |
dc.contributor.author | 이대중 | - |
dc.contributor.author | 송지훈 | - |
dc.contributor.author | 박도휘 | - |
dc.contributor.author | 전찬용 | - |
dc.contributor.author | 황귀서 | - |
dc.date.accessioned | 2022-04-18T01:40:08Z | - |
dc.date.available | 2022-04-18T01:40:08Z | - |
dc.date.created | 2022-04-18 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 1226-9174 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83983 | - |
dc.description.abstract | Objective: In this study, we investigated the protective effect of rhododendron mucronulatum extract (RME) on allergic reactions and inflammation. Methods: The effect of RME was determined using ELISA and RT-PCR in RBL-2H3 mast cells and RAW 264.7 macrophage cells. We determined cell viability, β-hexosaminidase release, and the synthesis of IL-4 and TNF-α in RBL-2H3 cells. In addition, we determined NO from RAW 264.7 and the gene expression of IL-1β, iNOS, IL-6, TNF-α, and IL-10. Results: RME inhibited β-hexosaminidase release and synthesis of IL-4 and TNF-α in RBL-2H3 by the anti-DNP IgE plus DNP-HSA stimulation. In addition, RME inhibited the production of NO and the gene expression of IL-1β, iNOS, IL-6, and TNF-α in LPS-stimulated RAW 264.7 cells. Conclusion: From these results, we concluded that RME possesses anti-allergic activity and anti-inflammatory activity due to the inhibition of mast cells and macrophage function. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한한방내과학회 | - |
dc.relation.isPartOf | 대한한방내과학회지 | - |
dc.title | 진달래 뿌리 추출물의 알레르기 염증 억제 효과 | - |
dc.title.alternative | Inhibitory Effect of Rhododendron Mucronulatum Root Extract on Allergic Inflammation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.22246/jikm.2022.43.1.68 | - |
dc.identifier.bibliographicCitation | 대한한방내과학회지, v.43, no.1, pp.68 - 78 | - |
dc.identifier.kciid | ART002830961 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 78 | - |
dc.citation.startPage | 68 | - |
dc.citation.title | 대한한방내과학회지 | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | 장시성 | - |
dc.contributor.affiliatedAuthor | 이대중 | - |
dc.contributor.affiliatedAuthor | 박도휘 | - |
dc.contributor.affiliatedAuthor | 전찬용 | - |
dc.contributor.affiliatedAuthor | 황귀서 | - |
dc.subject.keywordAuthor | Rhododendron Mucronulatum | - |
dc.subject.keywordAuthor | allergy | - |
dc.subject.keywordAuthor | β-hexosaminidase | - |
dc.subject.keywordAuthor | interleukin | - |
dc.subject.keywordAuthor | TNF-α | - |
dc.subject.keywordAuthor | NO | - |
dc.description.journalRegisteredClass | kci | - |
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