Evaluation of Serum Matrix Metalloproteinase-3 as an Objective Indicator for the Disease Activity in Rheumatoid Arthritis Patients Treated With Methotrexate Versus Tocilizumab: 24-week Results From a Prospective Randomized Controlled Study
DC Field | Value | Language |
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dc.contributor.author | 여지나 | - |
dc.contributor.author | 백한주 | - |
dc.contributor.author | 송영욱 | - |
dc.contributor.author | 이은영 | - |
dc.date.accessioned | 2022-04-19T01:40:09Z | - |
dc.date.available | 2022-04-19T01:40:09Z | - |
dc.date.created | 2022-04-18 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 2093-940X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84010 | - |
dc.description.abstract | Objective: This study aims to evaluate the change in serum metalloproteinase-3 (MMP-3) following the management of active rheumatoid arthritis (RA) and define the relationships between MMP-3 and disease activity indices. Methods: Data from a previously reported a 24-week, randomized controlled trial to investigate efficacy of tocilizumab in active RA refractory to methotrexate were analyzed. The serum level of MMP-3 were measured at week 0, 12, 20, and 24. The changes in MMP-3, and the relationship between MMP-3 and clinical parameters was assessed based on treatment group, methotrexate with or without tocilizumab. Results: A total of 95 patients were included in this study. The serum MMP-3 significantly decreased and showed similar pattern with other disease activity indices during treatment period in both treatment groups (p<0.001). The MMP-3 was positively correlated with ESR, CRP, DAS28, SDAI, and CDAI for 302 visits throughout 24 weeks (p<0.001). In another correlation analysis to evaluate the treatment effect at 24 week time point, methotrexate group showed significant correlation between serum markers: MMP-3 (r=0.321, p=0.043); ESR (r=0.450, p=0.002); and CRP (r=0.536, p<0.001), with DAS28, but tocilizumab group didn’t show meaningful correlation between serum markers and DAS28 (p>0.05). Conclusion: Serum MMP-3 showed positive correlation with disease activity indices in active RA patients. Furthermore, serum MMP-3 significantly decreased from baseline to week 20. As there is no single serum marker that can represent the disease activity particularly in tocilizumab treatment, MMP-3 might be a useful adjunct indicator to evaluate the treatment response in active RA patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한류마티스학회 | - |
dc.relation.isPartOf | 대한류마티스학회지 | - |
dc.title | Evaluation of Serum Matrix Metalloproteinase-3 as an Objective Indicator for the Disease Activity in Rheumatoid Arthritis Patients Treated With Methotrexate Versus Tocilizumab: 24-week Results From a Prospective Randomized Controlled Study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000782477500006 | - |
dc.identifier.doi | 10.4078/jrd.2022.29.2.89 | - |
dc.identifier.bibliographicCitation | 대한류마티스학회지, v.29, no.2, pp.89 - 97 | - |
dc.identifier.kciid | ART002827263 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85128858248 | - |
dc.citation.endPage | 97 | - |
dc.citation.startPage | 89 | - |
dc.citation.title | 대한류마티스학회지 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | 여지나 | - |
dc.contributor.affiliatedAuthor | 백한주 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Matrix metalloproteinase 3 | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | Methotrexate | - |
dc.subject.keywordAuthor | Tocilizumab | - |
dc.subject.keywordPlus | INTERLEUKIN-6 RECEPTOR INHIBITION | - |
dc.subject.keywordPlus | REMISSION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | LEAGUE | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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