Insulin secretion and alpha-glucosidase inhibitory effects of dicaffeoylquinic acid derivatives
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Lee, Hak-Dong | - |
dc.contributor.author | Kwon, Hyukjin | - |
dc.contributor.author | Lee, Hye Lim | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Choi, Sungyeol | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2022-04-19T08:40:09Z | - |
dc.date.available | 2022-04-19T08:40:09Z | - |
dc.date.created | 2022-04-19 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 2468-0834 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84036 | - |
dc.description.abstract | In this study, we investigated the effects of dicaffeoylquinic acid derivatives, including 1,4-di-O-caffeoylquinic acid (1,4-DCQA), 3,4-di-O-caffeoylquinic acid (3,4-DCQA), 3,5-di-O-caffeoylquinic acid (3,5-DCQA), 4,5-di-O-caffeoylquinic acid (4,5-DCQA), and 1,5-di-O-caffeoylquinic acid (1,5-DCQA) on glucose-stimulated insulin secretion (GSIS) activity and alpha-glucosidase activity were compared in rat INS-1 pancreatic beta-cells. The alpha-glucosidase inhibitory activities of dicaffeoylquinic acid derivatives were as follows: 1,4-DCQA > 1,5-DCQA > 3,4-DCQA > 4,5-DCQA > 3,5-DCQA. In INS-1 cells, dicaffeoylquinic acid derivatives showed no cytotoxic effect at any concentration (2.5-10 mu M). In addition, the GSIS activities of dicaffeoylquinic acid derivatives were as follows: 4,5-DCQA > 3,4-DCQA > 1,4-DCQA > 3,5-DCQA > 1,5-DCQA. Treatment of INS-1 cells with 4,5-DCQA resulted in a marked increase in protein expression of extracellular signal-regulated protein kinases (ERK), insulin receptor substrate-2 (P-IRS-2), Akt, phosphoinositide 3-kinase (P-PI3K), and pancreatic and duodenal homeobox-1 (PDX-1), which might be related to its GSIS activity in INS-1 cells. These findings indicate that the location of the dicaffeoyl functional group influences the anti-diabetic activity of quinic acid. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER SINGAPORE PTE LTD | - |
dc.relation.isPartOf | APPLIED BIOLOGICAL CHEMISTRY | - |
dc.title | Insulin secretion and alpha-glucosidase inhibitory effects of dicaffeoylquinic acid derivatives | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000774907100001 | - |
dc.identifier.doi | 10.1186/s13765-022-00688-9 | - |
dc.identifier.bibliographicCitation | APPLIED BIOLOGICAL CHEMISTRY, v.65, no.1, pp.1 - 9 | - |
dc.identifier.kciid | ART002834527 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85127472283 | - |
dc.citation.endPage | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | APPLIED BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 65 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.contributor.affiliatedAuthor | Choi, Sungyeol | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Dicaffeoylquinic acid derivatives | - |
dc.subject.keywordAuthor | Glucose-stimulated insulin secretion | - |
dc.subject.keywordAuthor | PDX-1 | - |
dc.subject.keywordPlus | FLOWER BUDS | - |
dc.subject.keywordPlus | L. | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.subject.keywordPlus | BURDOCK | - |
dc.subject.keywordPlus | ROOTS | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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