Mitigation of Gastric Damage Using Cinnamomum cassia Extract: Network Pharmacological Analysis of Active Compounds and Protection Effects in Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ji Hwan | - |
dc.contributor.author | Kwak, Hee Jae | - |
dc.contributor.author | Shin, Dongchul | - |
dc.contributor.author | Seo, Hye Jin | - |
dc.contributor.author | Park, Shin Jung | - |
dc.contributor.author | Hong, Bo-Hee | - |
dc.contributor.author | Shin, Myoung-Sook | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2022-04-19T08:40:18Z | - |
dc.date.available | 2022-04-19T08:40:18Z | - |
dc.date.created | 2022-04-19 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 2223-7747 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84046 | - |
dc.description.abstract | Gastritis is a common disease worldwide that is caused by various causes such as eating habits, smoking, severe stress, and heavy drinking, as well as Helicobacter pylori infections and non-steroidal anti-inflammatory drugs. Cinnamomum cassia is a tropical aromatic evergreen tree commonly used as a natural medicine in Asia and as a functional food ingredient. Studies have reported this species' anti-obesity, anti-diabetic, and cardiovascular disease suppression effects. We evaluated the potential effects of C. cassia using non-steroidal anti-inflammatory drugs (NSAIDs), ethanol (EtOH), and ethanol/hydrochloric acid (HCB-induced gastric mucosal injury models. C. cassia extracts reduced the area of gastric mucosa injury caused by indomethacin, NSAID, EtOH, and EtOH/HCl. We also applied a network pharmacology-based approach to identify the active compounds, potential targets, and pharmacological mechanisms of C. cassia against gastritis. Through a network pharmacology analysis, 10 key components were predicted as anti-gastritis effect-related compounds of C. cassia among 51 expected active compounds. The NF-KB signaling pathway, a widely known inflammatory response mechanism, comprised a major signaling pathway within the network pharmacology analysis. These results suggest that the anti-gastritis activities of C. cassia may be induced via the anti-inflammatory effects of key components, which suppress the inflammation-related genes and signaling pathways identified in this study. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | PLANTS-BASEL | - |
dc.title | Mitigation of Gastric Damage Using Cinnamomum cassia Extract: Network Pharmacological Analysis of Active Compounds and Protection Effects in Rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000774245000001 | - |
dc.identifier.doi | 10.3390/plants11060716 | - |
dc.identifier.bibliographicCitation | PLANTS-BASEL, v.11, no.6 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85126051285 | - |
dc.citation.title | PLANTS-BASEL | - |
dc.citation.volume | 11 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Lee, Ji Hwan | - |
dc.contributor.affiliatedAuthor | Shin, Dongchul | - |
dc.contributor.affiliatedAuthor | Shin, Myoung-Sook | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cinnamomum cassia | - |
dc.subject.keywordAuthor | acute gastric injury | - |
dc.subject.keywordAuthor | EtOH/HCl mixture | - |
dc.subject.keywordAuthor | indomethacin | - |
dc.subject.keywordAuthor | network pharmacological analysis | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI INFECTION | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | ULCER | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | MUCOSA | - |
dc.subject.keywordPlus | H-2-RECEPTOR | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.