Effects of early medication treatment and metformin use for cancer prevention in diabetes patients: a nationwide sample cohort study in Korea using extended landmark-time analysis
DC Field | Value | Language |
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dc.contributor.author | 서화정 | - |
dc.contributor.author | 오현숙 | - |
dc.date.accessioned | 2022-04-22T03:40:29Z | - |
dc.date.available | 2022-04-22T03:40:29Z | - |
dc.date.created | 2022-01-06 | - |
dc.date.issued | 2021-12-17 | - |
dc.identifier.issn | 1225-3596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84087 | - |
dc.description.abstract | OBJECTIVES: This study investigated the effectiveness of early medication treatment and metformin use for cancer prevention in type 2 diabetes patients. METHODS: Population-based cohort data were used from the Korean National Health Insurance Service-National Sample Cohort database (KNHIS-NSC) for 2002–2013. Patient-specific medication prescription status was defined by the landmark time (LMT; a fixed time after cohort entry), considering both pre- and post-LMT prescriptions to control methodological biases in observational research. The LMT was set to 2 years. Logistic regression analysis with multivariable adjustment was conducted to analyze cancer incidence by patient-specific medication prescription status. RESULTS: Only 33.4% of the subjects were prescribed medication early (before the LMT) with compliance. Cancer incidence in individuals with early prescription and compliance was 25% lower (odds ratio [OR],0.75; 95% confidence interval [CI], 0.67 to 0.84) than in those without. As early-prescribed medications, metformin monotherapy and metformin combination therapy were associated with 34% (OR, 0.66; 95% CI, 0.51 to 0.83) and 25% (OR, 0.75; 95% CI, 0.64 to 0.88) lower cancer risk than nonuse, respectively. Patients who were prescribed late (post-LMT) but did not comply with the prescription had a 24% (OR, 1.24; 95% CI, 0.97 to 1.58) higher cancer incidence than non-users. Among patients who started monotherapy early without changes throughout the entire follow-up period, those who started on metformin had a 37% (OR, 0.63; 95% CI, 0.41 to 0.99) lower risk of cancer than non-metformin users. CONCLUSIONS: Doctors must prescribe antidiabetic medication early, and patient compliance is required, regardless of the prescription time, to prevent cancer. Metformin monotherapy or combination therapy is recommended as an early prescription. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국역학회 | - |
dc.relation.isPartOf | Epidemiology and Health | - |
dc.title | Effects of early medication treatment and metformin use for cancer prevention in diabetes patients: a nationwide sample cohort study in Korea using extended landmark-time analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000780587700001 | - |
dc.identifier.doi | 10.4178/epih.e2021103 | - |
dc.identifier.bibliographicCitation | Epidemiology and Health, v.43, pp.1 - 9 | - |
dc.identifier.kciid | ART002798362 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85125679498 | - |
dc.citation.endPage | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Epidemiology and Health | - |
dc.citation.volume | 43 | - |
dc.contributor.affiliatedAuthor | 서화정 | - |
dc.contributor.affiliatedAuthor | 오현숙 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | Anticancer agents | - |
dc.subject.keywordAuthor | Medication compliance | - |
dc.subject.keywordAuthor | Metformin | - |
dc.subject.keywordAuthor | Drug prescription | - |
dc.subject.keywordPlus | IMMORTAL PERSON-TIME | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | BIAS | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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