Distinct Immune Response at 1 Year Post-COVID-19 According to Disease Severity
DC Field | Value | Language |
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dc.contributor.author | Kang, Chang Kyung | - |
dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Hong, Jisu | - |
dc.contributor.author | Kim, Gwanghun | - |
dc.contributor.author | Lee, Soojin | - |
dc.contributor.author | Chang, Euijin | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Kim, Ik Soo | - |
dc.contributor.author | Seo, Jun-Young | - |
dc.contributor.author | Song, Daesub | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Shin, Hyun Mu | - |
dc.contributor.author | Kim, Yong-Woo | - |
dc.contributor.author | Lee, Chang-Han | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Hang-Rae | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.date.accessioned | 2022-04-26T03:40:19Z | - |
dc.date.available | 2022-04-26T03:40:19Z | - |
dc.date.created | 2022-04-26 | - |
dc.date.issued | 2022-03-21 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84107 | - |
dc.description.abstract | BackgroundDespite the fact of ongoing worldwide vaccination programs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), understanding longevity, breadth, and type of immune response to coronavirus disease-19 (COVID-19) is still important to optimize the vaccination strategy and estimate the risk of reinfection. Therefore, we performed thorough immunological assessments 1 year post-COVID-19 with different severity. MethodsWe analyzed peripheral blood mononuclear cells and plasma samples at 1 year post-COVID-19 in patients who experienced asymptomatic, mild, and severe illness to assess titers of various isotypes of antibodies (Abs) against SARS-CoV-2 antigens, phagocytic capability, and memory B- and T-cell responses. FindingsA total of 24 patients (7, 9, and 8 asymptomatic, mild, and severe patients, respectively) and eight healthy volunteers were included in this study. We firstly showed that disease severity is correlated with parameters of immune responses at 1 year post-COVID-19 that play an important role in protecting against reinfection with SARS-CoV-2, namely, the phagocytic capacity of Abs and memory B-cell responses. InterpretationVarious immune responses at 1 year post-COVID-19, particularly the phagocytic capacity and memory B-cell responses, were dependent on the severity of the prior COVID-19. Our data could provide a clue for a tailored vaccination strategy after natural infection according to the severity of COVID-19. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN IMMUNOLOGY | - |
dc.title | Distinct Immune Response at 1 Year Post-COVID-19 According to Disease Severity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000779344300001 | - |
dc.identifier.doi | 10.3389/fimmu.2022.830433 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN IMMUNOLOGY, v.13 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85127955872 | - |
dc.citation.title | FRONTIERS IN IMMUNOLOGY | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Kim, Ik Soo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | antibody | - |
dc.subject.keywordAuthor | phagocytosis | - |
dc.subject.keywordAuthor | memory B cells | - |
dc.subject.keywordAuthor | memory T cells | - |
dc.subject.keywordPlus | T-CELL | - |
dc.subject.keywordPlus | SARS-COV-2 | - |
dc.subject.keywordPlus | REINFECTION | - |
dc.subject.keywordPlus | VACCINATION | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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