Association between SLCO1B1 polymorphism and methotrexate-induced hepatotoxicity: a systematic review and meta-analysis
- Authors
- Han, Ji Min; Choi, Kyung Hee; Lee, Hong Hyun; Gwak, Hye Sun
- Issue Date
- Jan-2022
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- hepatotoxicity; malignancies; methotrexate; T521C polymorphism
- Citation
- ANTI-CANCER DRUGS, v.33, no.1, pp.75 - 79
- Journal Title
- ANTI-CANCER DRUGS
- Volume
- 33
- Number
- 1
- Start Page
- 75
- End Page
- 79
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84132
- DOI
- 10.1097/CAD.0000000000001125
- ISSN
- 0959-4973
- Abstract
- Reports on the association between the solute carrier organic anion transporter 1B1 (SLCO1B1) T521C polymorphism and methotrexate-induced hepatotoxicity in patients with malignancies are inconsistent. This meta-analysis evaluated the association between the SLCO1B1 T521C polymorphism and methotrexate-induced hepatotoxicity. We performed a systematic review of previous reports from the PubMed, Web of Science, and EMBASE databases, and a meta-analysis was conducted. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to evaluate the effect of the SLCO1B1 T521C polymorphism on the occurrence of methotrexate-induced hepatotoxicity. In total, data from five studies including 465 patients were analyzed. Patients had received a high-dose methotrexate regimen (1-5 g/m(2)). The SLCO1B1 variant allele (C allele) carriers had a 1.9-fold higher risk of hepatotoxicity than wild-type homozygote carriers (TT; OR, 1.94; 95% CI, 1.14-3.31). This meta-analysis demonstrated that C allele carriers of the SLCO1B1 polymorphism had a higher risk of hepatotoxicity than patients with the TT genotype. The SLCO1B1 T521C polymorphism may be a useful predictor for methotrexate-induced hepatotoxicity in patients with malignancies.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84132)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.