Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response
DC Field | Value | Language |
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dc.contributor.author | Kim, Hong Sook | - |
dc.contributor.author | Kim, Byung-Hak | - |
dc.contributor.author | Jung, Joo Eun | - |
dc.contributor.author | Lee, Chang Seok | - |
dc.contributor.author | Lee, Hyun Gyu | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Lee, Kun Ho | - |
dc.contributor.author | You, Ho Jin | - |
dc.contributor.author | Chung, Myung-Hee | - |
dc.contributor.author | Ye, Sang-Kyu | - |
dc.date.available | 2020-02-28T02:42:55Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8415 | - |
dc.description.abstract | Human 8-oxoguanine DNA glycosylase 1 (OGG1) is the major DNA repair enzyme that plays a key role in excision of oxidative damaged DNA bases such as 8-oxoguainine (8-oxoG). Recent studies suggest another function of OGG1, namely that it may be involved in the endotoxin- or oxidative stress-induced inflammatory response. In this study, we investigated the role of OGG1 in the inflammatory response. OGG1 expression is increased in the organs of endotoxin-induced or myelin oligodendrocyte glycoprotein (MOG)-immunized mice and immune cells, resulting in induction of the expression of pro-inflammatory mediators at the transcriptional levels. Biochemical studies showed that signal transducer and activator of transcription 1 (STAT1) plays a key role in endotoxin-induced OGG1 expression and inflammatory response. STAT1 regulates the transcriptional activity of OGG1 through recruiting and binding to the gamma-interferon activation site (GAS) motif of the OGG1 promoter region, and chromatin remodeling by acetylation and dimethylation of lysine-14 and-4 residues of histone H3. In addition, OGG1 acts as a STAT1 coactivator and has transcriptional activity in the presence of endotoxin. The data presented here identifies a novel mechanism, and may provide new therapeutic strategies for the treatment of endotoxin-mediated inflammatory diseases. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | FREE RADICAL BIOLOGY AND MEDICINE | - |
dc.subject | BASE EXCISION-REPAIR | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | HUMAN OGG1 | - |
dc.subject | HISTONE MODIFICATIONS | - |
dc.subject | TRANSCRIPTION FACTORS | - |
dc.subject | RECEPTOR 4 | - |
dc.subject | MICE | - |
dc.subject | DAMAGE | - |
dc.subject | POLY(ADP-RIBOSE) | - |
dc.subject | PATHWAY | - |
dc.title | Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000371219400002 | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2015.10.415 | - |
dc.identifier.bibliographicCitation | FREE RADICAL BIOLOGY AND MEDICINE, v.93, pp.12 - 22 | - |
dc.identifier.scopusid | 2-s2.0-84956901761 | - |
dc.citation.endPage | 22 | - |
dc.citation.startPage | 12 | - |
dc.citation.title | FREE RADICAL BIOLOGY AND MEDICINE | - |
dc.citation.volume | 93 | - |
dc.contributor.affiliatedAuthor | Chung, Myung-Hee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Coactivator | - |
dc.subject.keywordAuthor | Endotoxin | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | OGG1 | - |
dc.subject.keywordAuthor | STAT1 | - |
dc.subject.keywordPlus | BASE EXCISION-REPAIR | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | HUMAN OGG1 | - |
dc.subject.keywordPlus | HISTONE MODIFICATIONS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | RECEPTOR 4 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | POLY(ADP-RIBOSE) | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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