Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Kyung Hee | - |
dc.contributor.author | Ah Jeong Kim | - |
dc.contributor.author | In Ja Son | - |
dc.contributor.author | Kyung-Hwan Kim | - |
dc.contributor.author | Ki-Bong Kim | - |
dc.contributor.author | Hyuk Ahn | - |
dc.contributor.author | Eun Bong Lee | - |
dc.date.accessioned | 2022-05-02T09:40:06Z | - |
dc.date.available | 2022-05-02T09:40:06Z | - |
dc.date.created | 2022-05-02 | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84190 | - |
dc.description.abstract | Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to interact with the oral anticoagulant warfarin and can cause a serious bleeding complication. In this study, we evaluated the risk factors for international normalized ratio (INR) increase, which is a surrogate marker of bleeding, after addition of an NSAID in a total of 98 patients who used warfarin. Patient age, sex, body mass index, maintenance warfarin dose, baseline INR, coadministered medications, underlying diseases, and liver and kidney functions were evaluated for possible risk factors with INR increase >= 15.0% as the primary end-point. Of the 98 patients, 39 (39.8%) showed an INR elevation of >= 15.0% after adding a NSAID to warfarin therapy. Multivariate analysis showed that high maintenance dose (>40 mg/week) of warfarin (P=0.001), the presence of coadministered medications (P=0.024), the use of meloxicam (P=0.025) and low baseline INR value (P=0.03) were the risk factors for INR increase in respect to NSAID-warfarin interaction. In conclusion, special caution is required when an NSAID is administered to warfarin users if patients are taking warfarin >40 mg/week and other medications interacting with warfarin. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한의학회 | - |
dc.relation.isPartOf | Journal of Korean Medical Science | - |
dc.title | Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000275145400001 | - |
dc.identifier.doi | 10.3346/jkms.2010.25.3.337 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.25, no.3, pp.337 - 341 | - |
dc.identifier.kciid | ART001420389 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-77952309339 | - |
dc.citation.endPage | 341 | - |
dc.citation.startPage | 337 | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 25 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Hee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Warfarin | - |
dc.subject.keywordAuthor | Anti-Inflammatory Agents | - |
dc.subject.keywordAuthor | Non-Steroidal | - |
dc.subject.keywordAuthor | Drug Interactions | - |
dc.subject.keywordPlus | POTENTIAL INTERACTION | - |
dc.subject.keywordPlus | CELECOXIB INTERACTION | - |
dc.subject.keywordPlus | ATRIAL-FIBRILLATION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CYP2C9 | - |
dc.subject.keywordPlus | ANTICOAGULATION | - |
dc.subject.keywordPlus | POLYMORPHISM | - |
dc.subject.keywordPlus | HEMORRHAGE | - |
dc.subject.keywordPlus | ROFECOXIB | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.