A Wearable Photobiomodulation Patch Using a Flexible Red-Wavelength OLED and Its In Vitro Differential Cell Proliferation Effects
- Authors
- Jeon, Yongmin; Choi, Hye-Ryung; Lim, Myungsub; Choi, Seungyeop; Kim, Hyuncheol; Kwon, Jeong Hyun; Park, Kyoung-Chan; Choi, Kyung Cheol
- Issue Date
- May-2018
- Publisher
- WILEY
- Keywords
- OLEDs; patches; photobiomodulation; wearables; wound healing
- Citation
- ADVANCED MATERIALS TECHNOLOGIES, v.3, no.5
- Journal Title
- ADVANCED MATERIALS TECHNOLOGIES
- Volume
- 3
- Number
- 5
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84334
- DOI
- 10.1002/admt.201700391
- ISSN
- 2365-709X
- Abstract
- Photobiomodulation (PBM) is a safe and noninvasive method that can provide various clinical effects. However, conventional PBM devices using point light sources, such as light-emitting diodes and lasers have various disadvantages, such as low flexibility, relatively heavy weight, and nonuniform effects. This paper presents a novel wearable PBM patch using a flexible red-wavelength organic light-emitting diode (OLED) surface light source, which can be attached to the human body as a personalized PBM platform. The palm-sized wearable PBM patch can be very light (0.82 g) and thin (676 mu m). It also has a reasonable operation life (>300 h), flexibility (20 mm bending radius), and low-temperature operation (<40 degrees C), and it can provide wide and safe application irrespective of location and time. Fibroblasts, a major type of dermal cells, play a key role in the wound healing process. The results show that OLEDs may have excellent in vitro wound healing effects because they effectively stimulate fibroblast proliferation (over 58% of control) and enhance fibroblast migration (over 46% of control) under various conditions. For maximum effect, peak wavelength control is necessary to optimize cell proliferation and enhance in vivo wound healing effects.
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