Procyanidins and Phlobatannins from the Twigs of Rosa multiflora and Their Neuroprotective Activity
DC Field | Value | Language |
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dc.contributor.author | Lee, Tae Hyun | - |
dc.contributor.author | Hong, Seong-Min | - |
dc.contributor.author | Yoon, Da Hye | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.accessioned | 2022-05-18T00:40:07Z | - |
dc.date.available | 2022-05-18T00:40:07Z | - |
dc.date.created | 2022-03-26 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84352 | - |
dc.description.abstract | Three new procyanidins (1-3), two new phlobatannins (6 and 7), a new flavan-3,4-diol glycoside (9), and a new neolignan glycoside (10), along with three previously reported compounds (4, 5, and 8) were isolated from the twigs of Rosa multiflora. The chemical structures of the new compounds (1-3, 6, 7, 9, and 10) were characterized by spectroscopic data interpretation, including NMR (1H and 13C NMR, 1H-1H COSY, HSQC, HMBC, and NOESY) and HRESIMS analysis. Experimental ECD data analysis was conducted to assign the absolute configurations of the new compounds (1-3, 6, 7, 9, and 10). The absolute configuration of the sugar moieties was verified through a chiral derivatization method and LC-MS analysis. All the isolated compounds (1-10) were evaluated for their anti-neuroinflammatory activity based on inhibitory effects on nitric oxide production using a lipopolysaccharide-stimulated murine microglia BV-2 cell line and for their neurotrophic effects on nerve growth factor induction in C6 glioma. © 2022 American Chemical Society and American Society of Pharmacognosy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | Journal of Natural Products | - |
dc.title | Procyanidins and Phlobatannins from the Twigs of Rosa multiflora and Their Neuroprotective Activity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000791431400016 | - |
dc.identifier.doi | 10.1021/acs.jnatprod.1c01033 | - |
dc.identifier.bibliographicCitation | Journal of Natural Products, v.85, no.4, pp.917 - 926 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85126574160 | - |
dc.citation.endPage | 926 | - |
dc.citation.startPage | 917 | - |
dc.citation.title | Journal of Natural Products | - |
dc.citation.volume | 85 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Hong, Seong-Min | - |
dc.contributor.affiliatedAuthor | Yoon, Da Hye | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE SPECTRA | - |
dc.subject.keywordPlus | CONDENSED TANNINS | - |
dc.subject.keywordPlus | ROOTS | - |
dc.subject.keywordPlus | LIGNANS | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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