Anti-Inflammatory Effect of Quercetin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid
DC Field | Value | Language |
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dc.contributor.author | Kim, Young-Jin | - |
dc.contributor.author | Park, Wansu | - |
dc.date.available | 2020-02-28T02:43:19Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8438 | - |
dc.description.abstract | Quercetin (3,3',4',5,6-pentahydroxyflavone) is a well-known antioxidant and a flavonol found in many fruits, leaves, and vegetables. Quercetin also has known anti-inflammatory effects on lipopolysaccharide-induced macrophages. However, the effects of quercetin on virus-induced macrophages have not been fully reported. In this study, the anti-inflammatory effect of quercetin on double-stranded RNA (dsRNA)-induced macrophages was examined. Quercetin at concentrations up to 50 mu M significantly inhibited the production of NO, IL-6, MCP-1, IP-10, RANTES, GM-CSF, G-CSF, TNF-alpha, LIF, LIX, and VEGF as well as calcium release in dsRNA (50 mu g/mL of polyinosinic-polycytidylic acid)-induced RAW 264.7 mouse macrophages (p < 0.05). Quercetin at concentrations up to 50 mu M also significantly inhibited mRNA expression of signal transducer and activated transcription 1 (STAT1) and STAT3 in dsRNA-induced RAW 264.7 cells (p < 0.05). In conclusion, quercetin had alleviating effects on viral inflammation based on inhibition of NO, cytokines, chemokines, and growth factors in dsRNA-induced macrophages via the calcium-STAT pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MOLECULES | - |
dc.subject | WATER EXTRACT | - |
dc.subject | INFLAMMATION | - |
dc.subject | ACTIVATION | - |
dc.subject | CYTOKINES | - |
dc.subject | IMMUNITY | - |
dc.subject | CELLS | - |
dc.title | Anti-Inflammatory Effect of Quercetin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000375155000063 | - |
dc.identifier.doi | 10.3390/molecules21040450 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.21, no.4 | - |
dc.identifier.scopusid | 2-s2.0-84966801165 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 21 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Kim, Young-Jin | - |
dc.contributor.affiliatedAuthor | Park, Wansu | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | quercetin | - |
dc.subject.keywordAuthor | dsRNA | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | macrophages | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | calcium | - |
dc.subject.keywordAuthor | STAT | - |
dc.subject.keywordPlus | WATER EXTRACT | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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