Pathophysiological Role of TLR4 in Chronic Relapsing Itch Induced by Subcutaneous Capsaicin Injection in Neonatal Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희주 | - |
dc.contributor.author | Lee, Eun-Hui | - |
dc.contributor.author | Lim, Yoon Hee | - |
dc.contributor.author | Jeong, Dongil | - |
dc.contributor.author | 나흥식 | - |
dc.contributor.author | 정윤재 | - |
dc.date.accessioned | 2022-05-28T02:40:08Z | - |
dc.date.available | 2022-05-28T02:40:08Z | - |
dc.date.created | 2022-05-06 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84450 | - |
dc.description.abstract | Despite the high prevalence of chronic dermatitis and the accompanied intractable itch, therapeutics that specifically target itching have low efficacy. Increasing evidence suggests that TLRs contribute to immune activation and neural sensitization; however, their roles in chronic itch remain elusive. Here, we show that the RBL-2H3 mast cell line expresses TLR4 and that treatment with a TLR4 antagonist opposes the LPS dependent increase in mRNA levels of Th2 and innate cytokines. The pathological role of TLR4 activation in itching was studied in neonate rats that developed chronic itch due to neuronal damage after receiving subcutaneous capsaicin injections. Treatment with a TLR4 antagonist protected these rats with chronic itch against scratching behavior and chronic dermatitis. TLR4 antagonist treatment also restored the density of cutaneous nerve fibers and inhibited the histopathological changes that are associated with mast cell activation after capsaicin injection. Additionally, the expression of IL-1β, IL-4, IL-5, IL-10, and IL-13 mRNA in the lesional skin decreased after TLR4 antagonist treatment. Based on these data, we propose that inhibiting TLR4 alleviated itch in a rat model of chronic relapsing itch, and the reduction in the itch was associated with TLR4 signaling in mast cells and nerve fibers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한면역학회 | - |
dc.relation.isPartOf | Immune Network | - |
dc.title | Pathophysiological Role of TLR4 in Chronic Relapsing Itch Induced by Subcutaneous Capsaicin Injection in Neonatal Rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000795575800007 | - |
dc.identifier.doi | 10.4110/in.2022.22.e20 | - |
dc.identifier.bibliographicCitation | Immune Network, v.22, no.2, pp.1 - 9 | - |
dc.identifier.kciid | ART002838012 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85130420281 | - |
dc.citation.endPage | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Immune Network | - |
dc.citation.volume | 22 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | 김희주 | - |
dc.contributor.affiliatedAuthor | Lee, Eun-Hui | - |
dc.contributor.affiliatedAuthor | Lim, Yoon Hee | - |
dc.contributor.affiliatedAuthor | Jeong, Dongil | - |
dc.contributor.affiliatedAuthor | 정윤재 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Itching | - |
dc.subject.keywordAuthor | Pruritus | - |
dc.subject.keywordAuthor | Capsaicin | - |
dc.subject.keywordAuthor | Mast cells | - |
dc.subject.keywordAuthor | Toll-like receptor 4 | - |
dc.subject.keywordAuthor | Th2 cells | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | ENDOGENOUS LIGANDS | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | PRURITUS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | RECEPTOR-4 | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.