Relationship Between Breast and Axillary Pathologic Complete Response According to Clinical Nodal Stage: A Nationwide Study From Korean Breast Cancer Society
DC Field | Value | Language |
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dc.contributor.author | 유재민 | - |
dc.contributor.author | 최희준 | - |
dc.contributor.author | 박은화 | - |
dc.contributor.author | 김지영 | - |
dc.contributor.author | 이영주 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 이지연 | - |
dc.contributor.author | 박흥규 | - |
dc.contributor.author | 남석진 | - |
dc.contributor.author | 김석원 | - |
dc.contributor.author | 이준희 | - |
dc.contributor.author | 이정언 | - |
dc.date.accessioned | 2022-05-28T02:40:09Z | - |
dc.date.available | 2022-05-28T02:40:09Z | - |
dc.date.created | 2022-04-30 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1738-6756 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84451 | - |
dc.description.abstract | Purpose: We evaluated the relationship between breast pathologic complete response (BpCR) and axillary pathologic complete response (ApCR) after neoadjuvant chemotherapy (NACT) according to nodal burden at presentation. As the indications for NACT have expanded, clinicians have started clinical trials for the omission of surgery from the treatment plan in patients with excellent responses to NACT. However, the appropriate indications for axillary surgery omission after excellent NACT response remain unclear. Methods: Data were collected from patients in the Korean Breast Cancer Society Registry who underwent NACT followed by surgery between 2010 and 2020. We analyzed pathologic axillary nodal positivity after NACT according to BpCR stratified by tumor subtype in patients with cT1-3/N0-2 disease at diagnosis. Results: A total of 6,597 patients were identified. Regarding cT stage, 528 (9.5%), 3,778 (67.8%), and 1,268 (22.7%) patients had cT1, cT2, and cT3 disease, respectively. Regarding cN stage, 1,539 (27.7%), 2,976 (53.6%), and 1,036 (18.7%) patients had cN0, cN1, and cN2 disease, respectively. BpCR occurred in 21.6% (n = 1,427) of patients, while ApCR and pathologic complete response (ypCR) occurred in 59.7% (n = 3,929) and ypCR 19.4% (n = 1,285) of patients, respectively. The distribution of biologic subtypes included 2,329 (39.3%) patients with hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative disease, 1,122 (18.9%) with HR-positive/HER2-positive disease, 405 (6.8%) with HR-negative/HER2-positive disease, and 2,072 (35.0%) with triple-negative breast cancer . Among the patients with BpCR, 89.6% (1,122/1,252) had ApCR. Of those with cN0 disease, most (99.0%, 301/304) showed ApCR. Among patients with cN1-2 disease, 86.6% (821/948) had ApCR. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국유방암학회 | - |
dc.relation.isPartOf | Journal of Breast Cancer | - |
dc.title | Relationship Between Breast and Axillary Pathologic Complete Response According to Clinical Nodal Stage: A Nationwide Study From Korean Breast Cancer Society | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000795704200002 | - |
dc.identifier.doi | 10.4048/jbc.2022.25.e17 | - |
dc.identifier.bibliographicCitation | Journal of Breast Cancer, v.25, no.2, pp.94 - 105 | - |
dc.identifier.kciid | ART002835102 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85133641963 | - |
dc.citation.endPage | 105 | - |
dc.citation.startPage | 94 | - |
dc.citation.title | Journal of Breast Cancer | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | 박흥규 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Breast Neoplasms | - |
dc.subject.keywordAuthor | Complete Response | - |
dc.subject.keywordAuthor | Neoadjuvant Therapy | - |
dc.subject.keywordPlus | SURGICAL ADJUVANT BREAST | - |
dc.subject.keywordPlus | NEOADJUVANT CHEMOTHERAPY | - |
dc.subject.keywordPlus | SENTINEL NODE | - |
dc.subject.keywordPlus | PREOPERATIVE CHEMOTHERAPY | - |
dc.subject.keywordPlus | CONSERVING THERAPY | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | PROTOCOL | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | WOMEN | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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