Can Kidney Transplantation Improve Arterial Stiffness in End-Stage Renal Patients?
- Authors
- Ro, H.; Kim, A. J.; Chang, J. H.; Jung, J. Y.; Chung, W. K.; Park, Y. H.; Lee, H. H.
- Issue Date
- Apr-2016
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- TRANSPLANTATION PROCEEDINGS, v.48, no.3, pp.884 - 886
- Journal Title
- TRANSPLANTATION PROCEEDINGS
- Volume
- 48
- Number
- 3
- Start Page
- 884
- End Page
- 886
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8446
- DOI
- 10.1016/j.transproceed.2015.12.080
- ISSN
- 0041-1345
- Abstract
- Background. Arterial stiffness is associated with cardiovascular disease in end-stage renal disease (ESRD) and after kidney transplantation. We examined how kidney transplantation influences brachial-ankle pulse-wave velocity (baPWV) in ESRD patients. Methods. The prospective observational study enrolled 67 patients who underwent successful kidney transplantation. Serial baPWV and biochemical parameters were measured before surgery and 6 months, 1 year, and 2 years after transplantation. Results. baPWV prior to kidney transplantation and 6 months, 1 year, and 2 years after transplantation was 1533 +/- 261 cm/s, 1417 +/- 254 cm/s, 1414 +/- 285 cm/s, and 1384 +/- 233 cm/s, respectively. baPWV and biochemical parameters including alkaline phosphatase, intact parathyroid hormone, and 1,25 hydroxyvitamin D improved significantly at 6 months (P < .05), but there were no changes between 6 months and 2 years after transplantation. The majority of patients (73%) improved, whereas the remainder showed progression of baPWV after transplantation. Sixty-three percent of all kidney transplantation patients displayed higher baPWV than the healthy control subjects at 6 months after transplant. Conclusions. In the majority of patients, baPWV improved soon after kidney transplantation but overall remained higher than in the generally healthy population.
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