The novel anti-neuroinflammatory functional food CCL01, a mixture of Cuscuta seed extracts and Lactobacillus paracasei NK112
DC Field | Value | Language |
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dc.contributor.author | Hong, Seong-Min | - |
dc.contributor.author | Ju, In Gyoung | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Park, Sang Cheol | - |
dc.contributor.author | Choi, Jin Gyu | - |
dc.contributor.author | Sohn, Mi Won | - |
dc.contributor.author | Oh, Myung Sook | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.date.accessioned | 2022-06-09T07:40:08Z | - |
dc.date.available | 2022-06-09T07:40:08Z | - |
dc.date.created | 2022-06-09 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 2042-650X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84549 | - |
dc.description.abstract | Neuroinflammation, which occurs due to microglia, is related to the pathogenesis of neurodegenerative disorders. Recently, the development of functional foods that down-regulate over-activated microglial cells to prevent the progression of neurodegenerative disorders has been proposed, since over-activated microglia induce a chronic source of neurotoxic factors and reduce neuronal survival. Thus, the anti-neuroinflammatory effects of a functional food mixture (CCL01) including Cuscuta seeds and Lactobacillus paracasei NK112 on lipopolysaccharide (LPS)-induced experimental models were investigated. In LPS-induced in vitro models, the expression levels of inflammatory mediators (e.g., inducible nitric oxide synthase, cyclooxygenase-2, nitric oxide, and prostaglandin E2) and pro-inflammatory cytokines (e.g., tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6) were decreased upon CCL01 treatment. CCL01 showed an anti-neuroinflammatory effect in LPS-induced microglial cells via the inhibition of the mitogen-activated protein kinase (MAPK)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) pathway and the activation of the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. In the LPS-treated in vivo mouse models, the increased expression of ionized calcium binding adaptor molecule 1 (Iba-1), which indicates microglial activity, was markedly decreased upon treatment with CCL01 (50 and 200 mg kg(-1)) in the hippocampus and cortex areas of the mouse brains in comparison with the LPS-injected group. In addition, the groups to which CCL01 was administered had significantly decreased plasma levels of tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6 in the LPS-injected mouse models. Our data suggest that CCL01 may be a potential anti-neuroinflammatory agent that can prevent microglia overactivation, and it could be useful for developing functional foods. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isPartOf | Food and Function | - |
dc.title | The novel anti-neuroinflammatory functional food CCL01, a mixture of Cuscuta seed extracts and Lactobacillus paracasei NK112 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000814524000001 | - |
dc.identifier.doi | 10.1039/D2FO01150F | - |
dc.identifier.bibliographicCitation | Food and Function, v.13, no.14, pp.7638 - 7649 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85132873657 | - |
dc.citation.endPage | 7649 | - |
dc.citation.startPage | 7638 | - |
dc.citation.title | Food and Function | - |
dc.citation.volume | 13 | - |
dc.citation.number | 14 | - |
dc.contributor.affiliatedAuthor | Hong, Seong-Min | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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