Ishophloroglucin A, Isolated from Ishige okamurae, Alleviates Dexamethasone-Induced Muscle Atrophy through Muscle Protein Metabolism In Vivo
DC Field | Value | Language |
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dc.contributor.author | Yang, Hye-Won | - |
dc.contributor.author | Oh, Seyeon | - |
dc.contributor.author | Chung, Dong-Min | - |
dc.contributor.author | Seo, Minyoung | - |
dc.contributor.author | Park, Shin Jae | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.contributor.author | Byun, Kyunghee | - |
dc.contributor.author | Ryu, BoMi | - |
dc.date.accessioned | 2022-06-09T07:40:11Z | - |
dc.date.available | 2022-06-09T07:40:11Z | - |
dc.date.created | 2022-06-03 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84553 | - |
dc.description.abstract | The in vitro capacity of Ishige okamurae extract (IO) to improve impaired muscle function has been previously examined. However, the mechanism underlying IO-mediated muscle protein metabolism and the role of its component, Ishophloroglucin A (IPA), in mice with dexamethasone (Dexa)-induced muscle atrophy remains unknown. In the present study, we evaluated the effect of IO and IPA supplementation on Dexa-induced muscle atrophy by assessing muscle protein metabolism in gastrocnemius and soleus muscles of mice. IO and IPA supplementation improved the Dexa-induced decrease in muscle weight and width, leading to enhanced grip strength. In addition, IO and IPA supplementation regulated impaired protein synthesis (PI3K and Akt) or degradation (muscle-specific ubiquitin ligase muscle RING finger and atrogin-1) by modulating mRNA levels in gastrocnemius and soleus muscles. Additionally, IO and IPA upregulated mRNA levels associated with muscle growth activation (transient receptor potential vanilloid type 4 and adenosine A1 receptor) or inhibition (myostatin and sirtuin 1) in gastrocnemius and soleus muscle tissues of Dexa-induced mice. Collectively, these results suggest that IO and IO-derived IPA can regulate muscle growth through muscle protein metabolism in Dexa-induced muscle atrophy. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | Marine Drugs | - |
dc.title | Ishophloroglucin A, Isolated from Ishige okamurae, Alleviates Dexamethasone-Induced Muscle Atrophy through Muscle Protein Metabolism In Vivo | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000802402700001 | - |
dc.identifier.doi | 10.3390/md20050280 | - |
dc.identifier.bibliographicCitation | Marine Drugs, v.20, no.5 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85129756919 | - |
dc.citation.title | Marine Drugs | - |
dc.citation.volume | 20 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Oh, Seyeon | - |
dc.contributor.affiliatedAuthor | Byun, Kyunghee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Ishige okamurae | - |
dc.subject.keywordAuthor | Ishophloroglucin A | - |
dc.subject.keywordAuthor | muscle atrophy | - |
dc.subject.keywordAuthor | muscle growth | - |
dc.subject.keywordAuthor | muscle protein metabolism | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | RAT SKELETAL | - |
dc.subject.keywordPlus | WASTING ROLE | - |
dc.subject.keywordPlus | STRENGTH | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordPlus | HYPERTROPHY | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MASS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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