Effects of compounds isolated from a Litsea japonica fruit extract on the TNF-alpha signaling pathway and cell viability
DC Field | Value | Language |
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dc.contributor.author | Won, Jiyeon | - |
dc.contributor.author | Kim, Jung-Eun | - |
dc.contributor.author | Choi, Dong Hwa | - |
dc.contributor.author | Han, Min-Woo | - |
dc.contributor.author | Lee, Doo-Hyung | - |
dc.contributor.author | Kang, Se Chan | - |
dc.contributor.author | Song, Yoon-Jae | - |
dc.date.available | 2020-02-28T02:43:39Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1738-642X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8455 | - |
dc.description.abstract | Tumor necrosis factor-alpha (TNF-alpha) plays an important role in inflammatory responses. Deregulated activation of TNF-alpha signaling is associated with various inflammatory diseases. In view of the finding that the seventy percent ethanol extract of Litsea japonica (LJE) interferes with TNF-alpha-induced NF-kappa B activation, activity -guided fractionation was performed to identify the active components of the extract. The EtOAc, CH2Cl2 and n-Hexane fractions of LJE induced suppression of inhibitor of kappa B (I kappa B) kinase (IKK), p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK), and significant reduction of TNF-alpha-induced NF-kappa B activation. From the CH2Cl2 fraction, hamabiwalactone A, hamabiwalactone B, litsenolide B2 and litsenolide C2 were identified to inhibit TNF-alpha-induced NF-kappa B activation. The cytotoxic activities of these lactone compounds were additionally evaluated. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT | - |
dc.relation.isPartOf | MOLECULAR & CELLULAR TOXICOLOGY | - |
dc.title | Effects of compounds isolated from a Litsea japonica fruit extract on the TNF-alpha signaling pathway and cell viability | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000373095200006 | - |
dc.identifier.doi | 10.1007/s13273-016-0006-1 | - |
dc.identifier.bibliographicCitation | MOLECULAR & CELLULAR TOXICOLOGY, v.12, no.1, pp.37 - 44 | - |
dc.identifier.kciid | ART002326488 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84962129563 | - |
dc.citation.endPage | 44 | - |
dc.citation.startPage | 37 | - |
dc.citation.title | MOLECULAR & CELLULAR TOXICOLOGY | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Won, Jiyeon | - |
dc.contributor.affiliatedAuthor | Kim, Jung-Eun | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hwa | - |
dc.contributor.affiliatedAuthor | Lee, Doo-Hyung | - |
dc.contributor.affiliatedAuthor | Kang, Se Chan | - |
dc.contributor.affiliatedAuthor | Song, Yoon-Jae | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Pro-inflammatory cytokine | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | Litsea japonica | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ANTI-COMPLEMENT ACTIVITY | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | PRODUCTS | - |
dc.subject.keywordPlus | LEAVES | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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