Male patients require higher optimal effect-site concentrations of propofol during i-gel insertion with dexmedetomidine 0.5 mu g/kg
DC Field | Value | Language |
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dc.contributor.author | Choi, Jung Ju | - |
dc.contributor.author | Kim, Ji Young | - |
dc.contributor.author | Lee, Dongchul | - |
dc.contributor.author | Chang, Young Jin | - |
dc.contributor.author | Cho, Noo Ree | - |
dc.contributor.author | Kwak, Hyun Jeong | - |
dc.date.available | 2020-02-28T02:43:44Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-03-22 | - |
dc.identifier.issn | 1471-2253 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8460 | - |
dc.description.abstract | Background: The pharmacokinetics and pharmacodynamics of an anesthetic drug may be influenced by gender. The purpose of this study was to compare effect-site half maximal effective concentrations (EC50) of propofol in male and female patients during i-gel insertion with dexmedetomidine 0.5 mu g/kg without muscle relaxants. Methods: Forty patients, aged 20-46 years of ASA physical status I or II, were allocated to one of two groups by gender (20 patients per group). After the infusion of dexmedetomidine 0.5 mu g/kg over 2 min, anesthesia was induced with a pre-determined effect-site concentration of propofol by target controlled infusion. Effect-site EC50 values of propofol for successful i-gel insertion were determined using the modified Dixon's up-and-down method. Results: Mean effect-site EC50 +/- SD of propofol for successful i-gel insertion was significantly higher for men than women (5.46 +/- 0.26 mu g/ml vs. 3.82 +/- 0.34 mu g/ml, p < 0.01). The EC50 of propofol in men was approximately 40 % higher than in women. Using isotonic regression with a bootstrapping approach, the estimated EC50 (95 % confidence interval) of propofol was also higher in men [5.32 (4.45-6.20) mu g/ml vs. 3.75 (3.05-4.43) mu g/ml]. The estimated EC95 (95 % confidence interval) of propofol in men and women were 5.93 (4.72-6.88) mu g/ml and 4.52 (3.02-5.70) mu g/ml, respectively. Conclusions: During i-gel insertion with dexmedetomidine 0.5 mu g/kg without muscle relaxant, male patients had higher effect-site EC50 for propofol using Schnider's model. Based on the results of this study, patient gender should be considered when determining the optimal dose of propofol during supraglottic airway insertion. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | BMC ANESTHESIOLOGY | - |
dc.subject | TARGET-CONTROLLED INFUSION | - |
dc.subject | LARYNGEAL MASK AIRWAY | - |
dc.subject | SUPRAGLOTTIC AIRWAY | - |
dc.subject | ANESTHESIA | - |
dc.subject | EC50 | - |
dc.subject | CONSCIOUSNESS | - |
dc.subject | REMIFENTANIL | - |
dc.subject | VOLUNTEERS | - |
dc.subject | GENDER | - |
dc.subject | FASTER | - |
dc.title | Male patients require higher optimal effect-site concentrations of propofol during i-gel insertion with dexmedetomidine 0.5 mu g/kg | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000372736300003 | - |
dc.identifier.doi | 10.1186/s12871-016-0186-1 | - |
dc.identifier.bibliographicCitation | BMC ANESTHESIOLOGY, v.16 | - |
dc.identifier.scopusid | 2-s2.0-85007499792 | - |
dc.citation.title | BMC ANESTHESIOLOGY | - |
dc.citation.volume | 16 | - |
dc.contributor.affiliatedAuthor | Choi, Jung Ju | - |
dc.contributor.affiliatedAuthor | Kim, Ji Young | - |
dc.contributor.affiliatedAuthor | Lee, Dongchul | - |
dc.contributor.affiliatedAuthor | Chang, Young Jin | - |
dc.contributor.affiliatedAuthor | Cho, Noo Ree | - |
dc.contributor.affiliatedAuthor | Kwak, Hyun Jeong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Propofol | - |
dc.subject.keywordAuthor | I-gel | - |
dc.subject.keywordAuthor | Dexmedetomidine | - |
dc.subject.keywordPlus | TARGET-CONTROLLED INFUSION | - |
dc.subject.keywordPlus | LARYNGEAL MASK AIRWAY | - |
dc.subject.keywordPlus | SUPRAGLOTTIC AIRWAY | - |
dc.subject.keywordPlus | ANESTHESIA | - |
dc.subject.keywordPlus | EC50 | - |
dc.subject.keywordPlus | CONSCIOUSNESS | - |
dc.subject.keywordPlus | REMIFENTANIL | - |
dc.subject.keywordPlus | VOLUNTEERS | - |
dc.subject.keywordPlus | GENDER | - |
dc.subject.keywordPlus | FASTER | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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