Effects of Bacillus Subtilis-Fermented White Sword Bean Extract on Adipogenesis and Lipolysis of 3T3-L1 Adipocytes
DC Field | Value | Language |
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dc.contributor.author | Choi, Yujeong | - |
dc.contributor.author | Kim, Da-Som | - |
dc.contributor.author | Lee, Min-Chul | - |
dc.contributor.author | Park, Seulgi | - |
dc.contributor.author | Lee, Joo-Won | - |
dc.contributor.author | Om, Ae-Son | - |
dc.date.accessioned | 2022-06-20T07:40:25Z | - |
dc.date.available | 2022-06-20T07:40:25Z | - |
dc.date.created | 2022-06-20 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2304-8158 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84684 | - |
dc.description.abstract | To investigate the adipogenesis and lipolysis effects of the Bacillus subtilis-fermented white sword bean extract (FWSBE) on 3T3-L1 adipocytes, we treated 3T3-L1 preadipocytes before and after differentiation with FWSBE and measured triglyceride, free glycerol, mRNA, and protein levels. First, FWSBE reduced the cell viability of 3T3-L1 pre-adipocytes under 1000 mu g/mL conditions. Triglyceride accumulation in 3T3-L1 pre-adipocytes was suppressed, and free glycerol content in mature 3T3-L1 adipocytes was increased in the FWSBE treatment groups, indicating that FWSBE has anti-obesity effects. Further, FWSBE suppressed adipogenesis in 3T3-L1 pre-adipocytes by lowering the protein levels of C/EBP alpha, PPAR gamma, and FAS and increasing the level of pACC and pAMPK. Additionally, FWSBE promoted lipolysis in mature 3T3-L1 adipocytes by increasing the transcription levels of Ppara, Acox, and Lcad and the protein levels of pHSL and ATGL. Thus, we suggest that FWSBE can be a potential dietary supplement because of its anti-obesity properties. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | FOODS | - |
dc.title | Effects of Bacillus Subtilis-Fermented White Sword Bean Extract on Adipogenesis and Lipolysis of 3T3-L1 Adipocytes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000665968500001 | - |
dc.identifier.doi | 10.3390/foods10061423 | - |
dc.identifier.bibliographicCitation | FOODS, v.10, no.6 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85109040800 | - |
dc.citation.title | FOODS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Lee, Min-Chul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Canavalia gladiata | - |
dc.subject.keywordAuthor | triglyceride | - |
dc.subject.keywordAuthor | glycerol | - |
dc.subject.keywordAuthor | AMP-activated protein kinase | - |
dc.subject.keywordAuthor | peroxisome proliferator-activated receptor | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | HORMONE-SENSITIVE LIPASE | - |
dc.subject.keywordPlus | MESSENGER-RNA LEVELS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | SUPPRESSES DIFFERENTIATION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | CANAVALIA-GLADIATA | - |
dc.subject.keywordPlus | ANTIOBESITY DRUGS | - |
dc.subject.keywordPlus | LIPID DROPLETS | - |
dc.subject.keywordPlus | RECEPTOR-GAMMA | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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