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Insulin Resistance: From Mechanisms to Therapeutic Strategies
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 이신해 | - |
| dc.contributor.author | 박시영 | - |
| dc.contributor.author | 최철수 | - |
| dc.date.accessioned | 2022-06-20T11:40:11Z | - |
| dc.date.available | 2022-06-20T11:40:11Z | - |
| dc.date.created | 2022-01-30 | - |
| dc.date.issued | 2022-01 | - |
| dc.identifier.issn | 2233-6079 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84734 | - |
| dc.description.abstract | Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin. Although the underlying mechanism of insulin resistance is not fully understood, several credible theories have been proposed. In this review, we summarize the functions of insulin in glucose metabolism in typical metabolic tissues and describe the mechanisms proposed to underlie insulin resistance, that is, ectopic lipid accumulation in liver and skeletal muscle, endoplasmic reticulum stress, and inflammation. In addition, we suggest potential therapeutic strategies for addressing insulin resistance. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | 대한당뇨병학회 | - |
| dc.relation.isPartOf | DIABETES & METABOLISM JOURNAL | - |
| dc.title | Insulin Resistance: From Mechanisms to Therapeutic Strategies | - |
| dc.type | Article | - |
| dc.type.rims | ART | - |
| dc.description.journalClass | 1 | - |
| dc.identifier.wosid | 000807972700003 | - |
| dc.identifier.doi | 10.4093/dmj.2021.0280 | - |
| dc.identifier.bibliographicCitation | DIABETES & METABOLISM JOURNAL, v.46, no.1, pp.15 - 37 | - |
| dc.identifier.kciid | ART002808255 | - |
| dc.description.isOpenAccess | N | - |
| dc.identifier.scopusid | 2-s2.0-85124438036 | - |
| dc.citation.endPage | 37 | - |
| dc.citation.startPage | 15 | - |
| dc.citation.title | DIABETES & METABOLISM JOURNAL | - |
| dc.citation.volume | 46 | - |
| dc.citation.number | 1 | - |
| dc.contributor.affiliatedAuthor | 이신해 | - |
| dc.contributor.affiliatedAuthor | 박시영 | - |
| dc.contributor.affiliatedAuthor | 최철수 | - |
| dc.type.docType | Review | - |
| dc.subject.keywordAuthor | Diabetes mellitus | - |
| dc.subject.keywordAuthor | type 2 | - |
| dc.subject.keywordAuthor | Insulin resistance | - |
| dc.subject.keywordAuthor | Metabolic syndrome | - |
| dc.subject.keywordAuthor | Therapeutics | - |
| dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
| dc.subject.keywordPlus | INDUCED HEPATIC STEATOSIS | - |
| dc.subject.keywordPlus | ELEMENT-BINDING PROTEIN | - |
| dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
| dc.subject.keywordPlus | GLUCOSE-INDUCED DESENSITIZATION | - |
| dc.subject.keywordPlus | HEXOSAMINE SYNTHESIS PATHWAY | - |
| dc.subject.keywordPlus | MUSCLE GLYCOGEN-SYNTHESIS | - |
| dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
| dc.subject.keywordPlus | FATTY-ACID OXIDATION | - |
| dc.subject.keywordPlus | DIET-INDUCED OBESITY | - |
| dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
| dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
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Related Researcher
- Choi, Cheol Soo
- College of Medicine (Premedical Course)