Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14
DC Field | Value | Language |
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dc.contributor.author | Kim, Ok-Hee | - |
dc.contributor.author | Kang, Geun-Hyung | - |
dc.contributor.author | Hur, June | - |
dc.contributor.author | Lee, Jinwook | - |
dc.contributor.author | Jung, YunJae | - |
dc.contributor.author | Hong, In-Sun | - |
dc.contributor.author | Lee, Hookeun | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.contributor.author | Lee, Cheol Soon | - |
dc.contributor.author | Lee, In-Kyu | - |
dc.contributor.author | Bonner-Weir, Susan | - |
dc.contributor.author | Lee, Jongsoon | - |
dc.contributor.author | Park, Young Joo | - |
dc.contributor.author | Kim, Hyeonjin | - |
dc.contributor.author | Shoelson, Steven E. | - |
dc.contributor.author | Oh, Byung-Chul | - |
dc.date.accessioned | 2022-06-21T08:40:07Z | - |
dc.date.available | 2022-06-21T08:40:07Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84745 | - |
dc.description.abstract | Apoptotic cells are rapidly engulfed and removed by phagocytes after displaying cell surface eat-me signals. Among many phospholipids, only phosphatidylserine (PS) is known to act as an eat-me signal on apoptotic cells. Using unbiased proteomics, we identified externalized phosphatidylinositides (PIPs) as apoptotic eat-me signals recognized by CD14(+) phagocytes. Exofacial PIPs on the surfaces of early and late-apoptotic cells were observed in patches and blebs using anti-PI(3,4,5)P-3 antibody, AKT- and PLC delta PH-domains, and CD14 protein. Phagocytosis of apoptotic cells was blocked either by masking exofacial PIPs or by CD14 knockout in phagocytes. We further confirmed that exofacial PIP+ thymocytes increased dramatically after in vivo irradiation and that exofacial PIP+ cells represented more significant populations in tissues of Cd14(-/-) than WT mice, especially after induction of apoptosis. Our findings reveal exofacial PIPs to be previously unknown cell death signals recognized by CD14(+) phagocytes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGERNATURE | - |
dc.relation.isPartOf | CELL DEATH AND DIFFERENTIATION | - |
dc.title | Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000741253200003 | - |
dc.identifier.doi | 10.1038/s41418-022-00931-2 | - |
dc.identifier.bibliographicCitation | CELL DEATH AND DIFFERENTIATION, v.29, no.7, pp.1423 - 1432 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85122678207 | - |
dc.citation.endPage | 1432 | - |
dc.citation.startPage | 1423 | - |
dc.citation.title | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.volume | 29 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Kim, Ok-Hee | - |
dc.contributor.affiliatedAuthor | Kang, Geun-Hyung | - |
dc.contributor.affiliatedAuthor | Hur, June | - |
dc.contributor.affiliatedAuthor | Lee, Jinwook | - |
dc.contributor.affiliatedAuthor | Jung, YunJae | - |
dc.contributor.affiliatedAuthor | Hong, In-Sun | - |
dc.contributor.affiliatedAuthor | Lee, Hookeun | - |
dc.contributor.affiliatedAuthor | Seo, Seung-Yong | - |
dc.contributor.affiliatedAuthor | Lee, Dae Ho | - |
dc.contributor.affiliatedAuthor | Oh, Byung-Chul | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordPlus | CD14-DEPENDENT CLEARANCE | - |
dc.subject.keywordPlus | PHOSPHATIDYLSERINE | - |
dc.subject.keywordPlus | PHOSPHOINOSITIDES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | PHAGOCYTOSIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ENDOCYTOSIS | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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