Differential Long-Term Effects of First- and Second-Generation DES in Patients With Bifurcation Lesions Undergoing PCI
DC Field | Value | Language |
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dc.contributor.author | Choi, K.H. | - |
dc.contributor.author | Song, Y.B. | - |
dc.contributor.author | Lee, J.M. | - |
dc.contributor.author | Park, T.K. | - |
dc.contributor.author | Yang, J.H. | - |
dc.contributor.author | Hahn, J.-Y. | - |
dc.contributor.author | Choi, J.-H. | - |
dc.contributor.author | Choi, S.-H. | - |
dc.contributor.author | Kim, H.-S. | - |
dc.contributor.author | Chun, W.J. | - |
dc.contributor.author | Hur, S.-H. | - |
dc.contributor.author | Han, S.H. | - |
dc.contributor.author | Rha, S.-W. | - |
dc.contributor.author | Chae, I.-H. | - |
dc.contributor.author | Jeong, J.-O. | - |
dc.contributor.author | Heo, J.H. | - |
dc.contributor.author | Yoon, J. | - |
dc.contributor.author | Lim, D.-S. | - |
dc.contributor.author | Park, J.-S. | - |
dc.contributor.author | Hong, M.-K. | - |
dc.contributor.author | Doh, J.-H. | - |
dc.contributor.author | Cha, K.S. | - |
dc.contributor.author | Kim, D.-I. | - |
dc.contributor.author | Lee, S.Y. | - |
dc.contributor.author | Chang, K. | - |
dc.contributor.author | Hwang, B.-H. | - |
dc.contributor.author | Choi, S.-Y. | - |
dc.contributor.author | Jeong, M.H. | - |
dc.contributor.author | Hong, S.-J. | - |
dc.contributor.author | Nam, C.-W. | - |
dc.contributor.author | Koo, B.-K. | - |
dc.contributor.author | Gwon, H.-C. | - |
dc.date.accessioned | 2022-06-26T09:40:07Z | - |
dc.date.available | 2022-06-26T09:40:07Z | - |
dc.date.created | 2022-06-26 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2772-3747 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84810 | - |
dc.description.abstract | Background: There is a paucity of data regarding the long-term clinical outcomes of first- versus second-generation drug-eluting stent (DES), especially when used to treat complex lesions such as bifurcation lesions. Objectives: The current study compares the efficacy and safety of first- versus second-generation DES at the 5-year follow-up in patients who underwent bifurcation percutaneous coronary intervention (PCI). Methods: A total of 5,498 patients with a bifurcation lesion who underwent PCI were pooled at a single patient level from COBIS (Coronary Bifurcation Stenting) registries II and III. Five-year target lesion failure (TLF) (the composite of cardiac death, myocardial infarction [MI], and target lesion revascularization [TLR]) and cardiac death or MI were compared between the use of first-generation DES (n = 2,436) and second-generation DES (n = 3,062) during PCI. Propensity score matching was performed to reduce selection bias. Results: After a 1:1 propensity score matching procedure was conducted, the cohort consisted of 1,702 matched pairs. Patients treated with second-generation DES had a significantly lower risk of TLF at 5 years than those treated with first-generation DES in both overall and propensity-matched populations (matched hazard ratio [HRmatched]: 0.576; 95% confidence interval [CI]: 0.456 to 0.727; p <0.001). There were no significant differences in risk of a composite of cardiac death or MI between the 2 groups (HRmatched: 0.782; 95% CI: 0.539 to 1.133, P = 0.193). However, among patients who required a 2-stent technique, use of the second-generation DES reduced cardiac death or MI (HRmatched:0.422; 95% CI: 0.209 to 0.851, P = 0.016). On the other hand, among patients who required a one-stent technique, the risk of a composite of cardiac death or MI was similar between the 2 groups (HRmatched: 1.046; 95% CI: 0.664 to 1.650, P = 0.845). There was a significant interaction between stent generation and treatment strategy for cardiac death or MI (interaction P = 0.029). Conclusions: In patients treated with PCI for a bifurcation lesion, the use of second-generation DES was associated with a significantly reduced risk of 5-year TLF than the use of first-generation DES. (Korean Coronary Bifurcation Stenting Registry II [NCT01642992]; COBIS II) (Korean Coronary Bifurcation Stenting Registry III [NCT03068494] COBIS III) © 2021 The Authors | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.isPartOf | JACC: Asia | - |
dc.title | Differential Long-Term Effects of First- and Second-Generation DES in Patients With Bifurcation Lesions Undergoing PCI | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.1016/j.jacasi.2021.04.006 | - |
dc.identifier.bibliographicCitation | JACC: Asia, v.1, no.1, pp.68 - 79 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85132199997 | - |
dc.citation.endPage | 79 | - |
dc.citation.startPage | 68 | - |
dc.citation.title | JACC: Asia | - |
dc.citation.volume | 1 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Han, S.H. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | bifurcation | - |
dc.subject.keywordAuthor | drug-eluting stents | - |
dc.subject.keywordAuthor | outcomes | - |
dc.subject.keywordAuthor | percutaneous coronary intervention | - |
dc.description.journalRegisteredClass | scopus | - |
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