N-Doped Carbon Nanorods from Biomass as a Potential Antidiabetic Nanomedicine
DC Field | Value | Language |
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dc.contributor.author | Park, Miey | - |
dc.contributor.author | Sharma, A. | - |
dc.contributor.author | Kang, Chaewon | - |
dc.contributor.author | Han, Jinyoung | - |
dc.contributor.author | Tripathi, M. | - |
dc.contributor.author | Lee, Hae-Jeung | - |
dc.date.accessioned | 2022-06-27T02:40:06Z | - |
dc.date.available | 2022-06-27T02:40:06Z | - |
dc.date.created | 2022-04-28 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2373-9878 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84812 | - |
dc.description.abstract | Insufficient glucose control remains a critical challenge for type 2 diabetes mellitus (T2DM) patients with currently used therapeutic drugs, which can also have detrimental side effects. The facile synthesis of nitrogendoped carbon nanorods (N-CNRs) as therapeutic agents in a T2DM transgenic db/db mouse model is reported herein. N-CNRs are synthesized from silkworm powder without the assistance of any template and possess a hollow graphitic nature, rough surface, and good aqueous solubility, which make them ideal candidates for fabricating nanomedicines. N-CNRs are employed to reduce fasting blood glucose and ameliorate serum biomarker levels linked to oxidative stress and inflammation. Interestingly, through the downregulation of enhanced expression of glutathione peroxidase, superoxide dismutase, and catalase as well as inflammatory responses, N-CNRs reverse pancreatic dysfunction and normalize the secretory functions of pancreatic cells. Moreover, hepatic steatosis is attenuated by downregulating lipogenesis and increasing fatty acid oxidation. This finding may help in designing novel therapeutics for T2DM treatment | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS BIOMATERIALS SCIENCE & ENGINEERING | - |
dc.title | N-Doped Carbon Nanorods from Biomass as a Potential Antidiabetic Nanomedicine | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000800651400033 | - |
dc.identifier.doi | 10.1021/acsbiomaterials.1c01598 | - |
dc.identifier.bibliographicCitation | ACS BIOMATERIALS SCIENCE & ENGINEERING, v.8, no.5, pp.2131 - 2141 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85129268699 | - |
dc.citation.endPage | 2141 | - |
dc.citation.startPage | 2131 | - |
dc.citation.title | ACS BIOMATERIALS SCIENCE & ENGINEERING | - |
dc.citation.volume | 8 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Park, Miey | - |
dc.contributor.affiliatedAuthor | Sharma, A. | - |
dc.contributor.affiliatedAuthor | Kang, Chaewon | - |
dc.contributor.affiliatedAuthor | Han, Jinyoung | - |
dc.contributor.affiliatedAuthor | Lee, Hae-Jeung | - |
dc.subject.keywordAuthor | carbon nanorods | - |
dc.subject.keywordAuthor | insulin resistance | - |
dc.subject.keywordAuthor | pancreatic protection | - |
dc.subject.keywordAuthor | type 2 diabetes mellitus | - |
dc.subject.keywordPlus | GRAPHENE NANOSHEETS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | DOTS | - |
dc.subject.keywordPlus | GLUCONEOGENESIS | - |
dc.subject.keywordPlus | NANOMATERIALS | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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