Regulation of appetite-related neuropeptides by Panax ginseng: A novel approach for obesity treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Phung, H.M. | - |
dc.contributor.author | Jang, Dongyeop | - |
dc.contributor.author | Trinh, T.A. | - |
dc.contributor.author | Lee, Donghun | - |
dc.contributor.author | Nguyen, Q.N. | - |
dc.contributor.author | Kim, Chang-Eop | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.accessioned | 2022-07-03T13:40:12Z | - |
dc.date.available | 2022-07-03T13:40:12Z | - |
dc.date.created | 2022-05-23 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84856 | - |
dc.description.abstract | Obesity is a primary factor provoking various chronic disorders, including cardiovascular disease, diabetes, and cancer, and causes the death of 2.8 million individuals each year. Diet, physical activity, medications, and surgery are the main therapies for overweightness and obesity. During weight loss therapy, a decrease in energy stores activates appetite signaling pathways under the regulation of neuropeptides, including anorexigenic [corticotropin-releasing hormone, proopiomelanocortin (POMC), cholecystokinin (CCK), and cocaine- and amphetamine-regulated transcript] and orexigenic [agouti-related protein (AgRP), neuropeptide Y (NPY), and melanin-concentrating hormone] neuropeptides, which increase food intake and lead to failure in attaining weight loss goals. Ginseng and ginsenosides reverse these signaling pathways by suppressing orexigenic neuropeptides (NPY and AgRP) and provoking anorexigenic neuropeptides (CCK and POMC), which prevent the increase in food intake. Moreover, the results of network pharmacology analysis have revealed that constituents of ginseng radix, including campesterol, beta-elemene, ginsenoside Rb1, biotin, and pantothenic acid, are highly correlated with neuropeptide genes that regulate energy balance and food intake, including ADIPOQ, NAMPT, UBL5, NUCB2, LEP, CCK, GAST, IGF1, RLN1, PENK, PDYN, and POMC. Based on previous studies and network pharmacology analysis data, ginseng and its compounds may be a potent source for obesity treatment by regulating neuropeptides associated with appetite. © 2022 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC GINSENG | - |
dc.relation.isPartOf | Journal of Ginseng Research | - |
dc.title | Regulation of appetite-related neuropeptides by Panax ginseng: A novel approach for obesity treatment | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000814322400012 | - |
dc.identifier.doi | 10.1016/j.jgr.2022.03.007 | - |
dc.identifier.bibliographicCitation | Journal of Ginseng Research, v.46, no.4, pp.609 - 619 | - |
dc.identifier.kciid | ART002856708 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85127808413 | - |
dc.citation.endPage | 619 | - |
dc.citation.startPage | 609 | - |
dc.citation.title | Journal of Ginseng Research | - |
dc.citation.volume | 46 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Phung, H.M. | - |
dc.contributor.affiliatedAuthor | Jang, Dongyeop | - |
dc.contributor.affiliatedAuthor | Trinh, T.A. | - |
dc.contributor.affiliatedAuthor | Lee, Donghun | - |
dc.contributor.affiliatedAuthor | Nguyen, Q.N. | - |
dc.contributor.affiliatedAuthor | Kim, Chang-Eop | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Appetite | - |
dc.subject.keywordAuthor | Food intake | - |
dc.subject.keywordAuthor | Ginsenosides | - |
dc.subject.keywordAuthor | Network pharmacology analysis | - |
dc.subject.keywordAuthor | Neuropeptide | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Panax ginseng | - |
dc.subject.keywordPlus | HIGH-FAT DIET | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | KOREAN RED GINSENG | - |
dc.subject.keywordPlus | HEPATIC LIPID-ACCUMULATION | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | PRACTICE GUIDELINES | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | BARIATRIC SURGERY | - |
dc.subject.keywordPlus | AMPK ACTIVATION | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.