Basilar artery tortuosity as a predictive factor for the efficacy of heparin adjuvant therapy in unilateral idiopathic sudden sensorineural hearing loss
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sunwoo, Woongsang | - |
dc.date.accessioned | 2022-07-03T13:40:13Z | - |
dc.date.available | 2022-07-03T13:40:13Z | - |
dc.date.created | 2020-08-31 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 1808-8694 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84857 | - |
dc.description.abstract | Introduction: Cochlear ischemia is hypothesized as one of the major etiologies of idiopathic sudden sensorineural hearing loss. Therefore, anticoagulant therapies are designed to be beneficial in certain patients with this condition. Objective: This study aimed to determine which patients with idiopathic sudden sensorineural hearing loss would benefit from heparin treatment as adjuvant therapy. Methods: In total, 134 patients who underwent magnetic resonance imaging for unilateral idiopathic sudden sensorineural hearing loss at a tertiary referral hospital between January 2014 and December 2018 were included in this retrospective study. All patients received Intratympanic steroid injections or heparin therapy plus oral corticosteroids. Radiological parameters of the vertebrobasilar system and clinical data from pre- and post-treatment assessments were analyzed. Results: Most patients (71.6%) had a tortuous basilar artery The 65 patients with severe-to-profound idiopathic sudden sensorineural hearing loss showed a significant relationship between idiopathic sudden sensorineural hearing loss laterality and basilar artery displacement to the opposite side (p = 0.036), while the 69 patients with mild-to-moderate idiopathic sudden sensorineural hearing loss did not (p = 0.950). Additionally, the degree of basilar artery tortuosity was significantly associated with the degree of hearing impairment in the severe-to-profound idiopathic sudden sensorineural hearing loss group (p = 0.015). When idiopathic sudden sensorineural hearing loss occurred on the opposite side to basilar artery displacement, the improvement of hearing was significantly greater in patients treated with heparin than in those treated with intratympanic steroids (p = 0.041). Conclusion: In a subset of patients with severe-to-profound idiopathic sudden sensorineural hearing loss, basilar artery tortuosity had a significant directional relationship with idiopathic sudden sensorineural hearing loss laterality. In these selected patients, a significant effect of heparin therapy on improving hearing was observed. © 2020 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL | - |
dc.relation.isPartOf | Brazilian Journal of Otorhinolaryngology | - |
dc.title | Basilar artery tortuosity as a predictive factor for the efficacy of heparin adjuvant therapy in unilateral idiopathic sudden sensorineural hearing loss | - |
dc.title.alternative | Tortuosidade da artéria basilar como fator preditivo da eficácia da terapia adjuvante com heparina na perda auditiva neurossensorial súbita idiopática unilateral | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000810701200014 | - |
dc.identifier.doi | 10.1016/j.bjorl.2020.06.017 | - |
dc.identifier.bibliographicCitation | Brazilian Journal of Otorhinolaryngology, v.88, no.3, pp.381 - 389 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85089828528 | - |
dc.citation.endPage | 389 | - |
dc.citation.startPage | 381 | - |
dc.citation.title | Brazilian Journal of Otorhinolaryngology | - |
dc.citation.volume | 88 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Sunwoo, Woongsang | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Basilar artery | - |
dc.subject.keywordAuthor | Hearing loss, unilateral | - |
dc.subject.keywordAuthor | Heparin | - |
dc.subject.keywordAuthor | Ischemia | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordPlus | SENSORINEURAL HEARING-LOSS | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.