Effect of Icodextrin Solution on the Preservation of Residual Renal Function in Peritoneal Dialysis Patients A Randomized Controlled Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Tae Ik | - |
dc.contributor.author | Ryu, Dong-Ryeol | - |
dc.contributor.author | Yoo, Tae-Hyun | - |
dc.contributor.author | Kim, Hyung Jong | - |
dc.contributor.author | Kang, Ea Wha | - |
dc.contributor.author | Kim, Hyunwook | - |
dc.contributor.author | Chang, Jae Hyun | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.contributor.author | Moon, Sung Jin | - |
dc.contributor.author | Yoon, Soo Young | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.date.available | 2020-02-28T02:44:06Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8485 | - |
dc.description.abstract | Although icodextrin solution has been highlighted in the fluid management compared to glucose-based solutions, proof of a beneficial effect of icodextrin solution on residual renal function (RRF) is lacking. We conducted a multicenter prospective randomized controlled open-label trial to investigate whether icodextrin solution can preserve RRF. One hundred patients with urine volume >= 750 mL/day from 8 centers in Korea were randomly assigned to receive 1 exchange of icodextrin solution for a >= 8 hour-dwell time and 2 exchanges of 1.5% glucose-based biocompatible neutral pH solution or 1 exchange of >= 2.5% and 2 exchanges of 1.5% glucose-based biocompatible solutions. Using mixed-effects general linear models, we analyzed changes in residual glomerular filtration rate (GFR) and daily urine volume at 1 year. Forty-nine patients were assigned to the icodextrin group and 51 to the glucose solution group. During follow-up, the slope of the decline in residual GFR was -0.170mL/min/month/1.73m(2) in the icodextrin group, while it was -0.155mL/min/month/1.73m(2) in the glucose solution group (95% confidence interval [CI], -0.06 to 0.10; P=0.701). Daily urine volume decreased faster in the glucose solution group than in the icodextrin group (-31.02 vs -11.88mL per month; 95% CI, -35.85 to -2.44; P=0.025). Results were consistent when we analyzed using intention-to-treat and per protocol principles. There were no differences in fluid status, peritoneal ultrafiltration, and peritoneal transport between groups during follow-up. This study clearly showed that icodextrin solution preserves residual urine volume better than glucose solution. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | MEDICINE | - |
dc.subject | INCIDENT CAPD PATIENTS | - |
dc.subject | CONTROLLED-TRIAL | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | DIABETIC-PATIENTS | - |
dc.subject | VOLUME STATUS | - |
dc.subject | ULTRAFILTRATION FAILURE | - |
dc.subject | TECHNIQUE SURVIVAL | - |
dc.subject | FLUID MANAGEMENT | - |
dc.subject | URINE VOLUME | - |
dc.subject | GLUCOSE | - |
dc.title | Effect of Icodextrin Solution on the Preservation of Residual Renal Function in Peritoneal Dialysis Patients A Randomized Controlled Study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000375256500001 | - |
dc.identifier.doi | 10.1097/MD.0000000000002991 | - |
dc.identifier.bibliographicCitation | MEDICINE, v.95, no.13 | - |
dc.identifier.scopusid | 2-s2.0-84962665137 | - |
dc.citation.title | MEDICINE | - |
dc.citation.volume | 95 | - |
dc.citation.number | 13 | - |
dc.contributor.affiliatedAuthor | Chang, Jae Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INCIDENT CAPD PATIENTS | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | DIABETIC-PATIENTS | - |
dc.subject.keywordPlus | VOLUME STATUS | - |
dc.subject.keywordPlus | ULTRAFILTRATION FAILURE | - |
dc.subject.keywordPlus | TECHNIQUE SURVIVAL | - |
dc.subject.keywordPlus | FLUID MANAGEMENT | - |
dc.subject.keywordPlus | URINE VOLUME | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.