Alcohol consumption on unprovoked seizure and epilepsy: An updated meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Woo, Kyoung Nam | - |
dc.contributor.author | Kim, Kihun | - |
dc.contributor.author | Ko, Dai Sik | - |
dc.contributor.author | Kim, Hyun-Woo | - |
dc.contributor.author | Kim, Yun Hak | - |
dc.date.accessioned | 2022-07-14T15:40:08Z | - |
dc.date.available | 2022-07-14T15:40:08Z | - |
dc.date.created | 2022-01-22 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 0376-8716 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84951 | - |
dc.description.abstract | Background: Epilepsy is one of the most common neurological disorders, affecting approximately 50 million people worldwide. Although a positive association between alcohol consumption and epilepsy has been demonstrated in previous meta-analyses of case-control studies, the results of several recently published large cohort studies are contradictory. Therefore, we conducted an updated meta-analysis that included more recent data to clarify the association between alcohol consumption and epilepsy. Methods: The search was performed on 25 January 2021 using the Embase and MEDLINE databases. Cohort or case-control studies were eligible for inclusion in this study. We used restricted cubic spline analysis to perform a dose-response meta-analysis. Results: A total of eight studies, including three cohort and five case-control studies, were included in our meta-analysis. The pooled risk of epilepsy was 1.70 (1.16–2.49) in alcohol users compared to non-drinkers. Subgroup analysis of 50 g units showed that the epilepsy risk increased as alcohol intake increased. The pooled risk of cohort studies was 1.00 (0.65–1.54), and the pooled risk of case-control studies was 2.61 (1.29–5.29). According to the dose-response analysis, the regression coefficient was 1.009 (1.004–1.014), indicating a significant positive dose-response relationship. Conclusion: Unlike the case-control studies, the cohort studies did not reveal a significant association between alcohol consumption and epilepsy. Further large cohort studies for the general population are required to assert a definite causal relationship between alcohol consumption and epilepsy and to identify a potential threshold. © 2022 Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Ireland Ltd | - |
dc.relation.isPartOf | Drug and Alcohol Dependence | - |
dc.title | Alcohol consumption on unprovoked seizure and epilepsy: An updated meta-analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000820117400028 | - |
dc.identifier.doi | 10.1016/j.drugalcdep.2022.109305 | - |
dc.identifier.bibliographicCitation | Drug and Alcohol Dependence, v.232 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85122811259 | - |
dc.citation.title | Drug and Alcohol Dependence | - |
dc.citation.volume | 232 | - |
dc.contributor.affiliatedAuthor | Ko, Dai Sik | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alcohol consumption | - |
dc.subject.keywordAuthor | Case-control study | - |
dc.subject.keywordAuthor | Cohort study | - |
dc.subject.keywordAuthor | Dose-response relationship | - |
dc.subject.keywordAuthor | Epilepsy | - |
dc.relation.journalResearchArea | Substance Abuse | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Substance Abuse | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
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