전신 질환에 의한 가려움증의 원인 및 기전에 관한 최신 동향

Abstract

Pruritus is a sensation that evokes a desire to scratch the skin. In particular, pruritus can be a burden foraffected people when it becomes severe and chronic, as it deteriorates the quality of life. Dermatological diseases such asatopic dermatitis are mostly recognized as major pruritus-related disorders. Surprisingly, some non-dermatological systemicdiseases may can also cause evoke pruritus. In this review, we summarized the underlying causes and mechanisms of threenon-dermatological pruritus-related systemic diseases that are not related to dermatological pruritus: including chronickidney disease, cholestatic liver disease, and neoplasm. In addition, we discussed recent research observations and noveltherapeutic strategies are discussed.