Hypertriglyceridemia and Cardiovascular Diseases: Revisited
- Authors
- Han, Seung Hwan; Nicholls, Stephen J.; Sakuma, Ichiro; Zhao, Dong; Koh, Kwang Kon
- Issue Date
- Mar-2016
- Publisher
- KOREAN SOC CARDIOLOGY
- Keywords
- Residual cardiovascular risk; Hypertriglyceridemia; Treatment; Cardiovascular disease
- Citation
- KOREAN CIRCULATION JOURNAL, v.46, no.2, pp.135 - 144
- Journal Title
- KOREAN CIRCULATION JOURNAL
- Volume
- 46
- Number
- 2
- Start Page
- 135
- End Page
- 144
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8523
- DOI
- 10.4070/kcj.2016.46.2.135
- ISSN
- 1738-5520
- Abstract
- Residual cardiovascular risk and failure of high density lipoprotein cholesterol raising treatment have refocused interest on targeting hypertriglyceridemia. Hypertriglyceridemia, triglyceride-rich lipoproteins, and remnant cholesterol have demonstrated to be important risk factors for cardiovascular disease; this has been demonstrated in experimental, genetic, and epidemiological studies. Fibrates can reduce cardiovascular event rates with or without statins. High dose omega-3 fatty acids continue to be evaluated and new specialized targeting treatment modulating triglyceride pathways, such as inhibition of apolipoprotein C-III and angiopoietin-like proteins, are being tested with regard to their effects on lipid profiles and cardiovascular outcomes. In this review, we will discuss the role of hypertriglyceridemia, triglyceride-rich lipoproteins and remnant cholesterol on cardiovascular disease, and the potential implications for treatment stargeting hypertriglyceridemia.
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