Severity Evaluation of Regional Cerebrovascular Reactivity in Acute Stroke Patients using SPECT
- Authors
- Kang, Chang-Ki; Song, Min-Gyu; Yang, Jiwon; Lee, Haejun; Lee, Yeong-Bae
- Issue Date
- Aug-2022
- Publisher
- Bentham Science Publishers
- Keywords
- acetazolamide; acute stroke; cerebral severity; cerebrovascular reactivity; PET; SPECT
- Citation
- Current Medical Imaging, v.18, no.8, pp.837 - 844
- Journal Title
- Current Medical Imaging
- Volume
- 18
- Number
- 8
- Start Page
- 837
- End Page
- 844
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85269
- DOI
- 10.2174/1573405618666220103104726
- ISSN
- 1573-4056
- Abstract
- Background: Cerebrovascular Reactivity (CVR), as measured using perfusion Single Photon Emission Computed Tomography (SPECT), is an important indicator for the treatment and prognosis of cerebrovascular disease, but there are a few studies on acute stroke or small vascular disease using SPECT. Objective: This study evaluated the regional severity with quantitatively determined CVR in patients with acute stroke. Methods: Fifty-eight patients who took brain SPECT images were selected to localize quantitative CVR values. The severity of the disease (Grade 1 to 4) was determined through image-based clinical assessment in the absence and presence of a CVR map, and their results were compared. Results: In 1st diagnosis without the map, the mean CVR values of Grades 2 and 3 were -6.07 % and -9.12 %, respectively (P=0.034), while they were -4.78 % and -12.34 % in 2nd diagnosis with the map, respectively (P<0.001), suggesting that the CVR difference with the map was much more pronounced than without the map. Furthermore, in the ROC analysis, the diagnostic sensitivity between Grades 2 and 3 in the 2nd diagnosis (AUC=0.899, P<0.001) was substantially greater than the 1st diagnosis (AUC=0.646, P=0.048). Conclusion: This study demonstrated that the quantitative CVR maps could reinforce the clinical evaluation of cerebral severity by showing that they can provide statistically significant results between severity and CVR. Furthermore, this study was the first to evaluate the effectiveness of quantitative CVR by examining the difference in the presence or absence of CVR in patients with acute stroke. © 2022 Bentham Science Publishers.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
- 보건과학대학 > 방사선학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85269)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.