Taeanamides A and B, Nonribosomal Lipo-Decapeptides Isolated from an Intertidal-Mudflat-Derived Streptomyces sp.
DC Field | Value | Language |
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dc.contributor.author | Cui, Jinsheng | - |
dc.contributor.author | Kim, Eunji | - |
dc.contributor.author | Moon, Dong Hyun | - |
dc.contributor.author | Kim, Tae Ho | - |
dc.contributor.author | Kang, Ilnam | - |
dc.contributor.author | Lim, Yeonjung | - |
dc.contributor.author | Shin, Daniel | - |
dc.contributor.author | Hwang, Sunghoon | - |
dc.contributor.author | Du, Young Eun | - |
dc.contributor.author | Song, Myoung Chong | - |
dc.contributor.author | Bae, Munhyung | - |
dc.contributor.author | Cho, Jang-Cheon | - |
dc.contributor.author | Jang, Jichan | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.contributor.author | Yoon, Yeo Joon | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.date.accessioned | 2022-08-29T16:40:10Z | - |
dc.date.available | 2022-08-29T16:40:10Z | - |
dc.date.created | 2022-08-19 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85334 | - |
dc.description.abstract | Two new lipo-decapeptides, namely taeanamides A and B (1 and 2), were discovered from the Gram-positive bacterium Streptomyces sp. AMD43, which was isolated from a mudflat sample from Anmyeondo, Korea. The exact molecular masses of 1 and 2 were revealed by high-resolution mass spectrometry, and the planar structures of 1 and 2 were elucidated using NMR spectroscopy. The absolute configurations of 1 and 2 were determined using a combined analysis of H-1-H-1 coupling constants and ROESY correlations, the advanced Marfey's method, and bioinformatics. The putative nonribosomal peptide synthetase pathway for the taeanamides was identified by analyzing the full genome sequence data of Streptomyces sp. AMD43. We also found that taeanamide A exhibited mild anti-tuberculosis bioactivity, whereas taeanamide B showed significant bioactivity against several cancer cell lines. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MARINE DRUGS | - |
dc.title | Taeanamides A and B, Nonribosomal Lipo-Decapeptides Isolated from an Intertidal-Mudflat-Derived Streptomyces sp. | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000815973600001 | - |
dc.identifier.doi | 10.3390/md20060400 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.20, no.6 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85132550929 | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 20 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Bae, Munhyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | intertidal mudflat | - |
dc.subject.keywordAuthor | Streptomyces sp | - |
dc.subject.keywordAuthor | anti-tuberculosis | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | nonribosomal peptide synthetase | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | FERMENTATION | - |
dc.subject.keywordPlus | LIPOPEPTIDES | - |
dc.subject.keywordPlus | THIOCORALINE | - |
dc.subject.keywordPlus | SURFACTIN | - |
dc.subject.keywordPlus | TAXONOMY | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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