Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Se-Ra | - |
dc.contributor.author | Kim, Seong-Kwan | - |
dc.contributor.author | Kim, Soo-Rim | - |
dc.contributor.author | Park, Jeong-Ran | - |
dc.contributor.author | Lim, Soyi | - |
dc.contributor.author | Hong, In-Sun | - |
dc.date.accessioned | 2022-09-16T01:40:06Z | - |
dc.date.available | 2022-09-16T01:40:06Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85464 | - |
dc.description.abstract | Luteinizing hormone (LH) stimulates the synthesis and secretion of the key steroid hormone estrogen, which subsequently promotes ovarian follicular growth and development. Therefore, the administration of exogenous LH to achieve superovulation (multiple ovulations) and an LH surge is commonly used as the most effective therapeutic option in a majority of in vitro fertilization (IVF) clinics. However, a relatively low pregnancy rate (between 20% and 35%) is one of the most challenging aspects of LH-based infertility treatment. Furthermore, the major cause of this low pregnancy rate in LH-based infertility treatment remains unidentified. Recent studies have shown that endometrial stem cell loss or deficiency can significantly decrease tissue regeneration ability during the menstrual cycle and reduce endometrial receptivity. In this context, we postulated that the low pregnancy rates following LH-based ovarian hyperactivation may be the result of the adverse effects of consecutive exogenous LH administration on endometrial stem cells. To the best of our knowledge, this study revealed for the first time that in addition to its previously reported roles in stimulating ovarian functions through the pituitary-gonadal axis, LH brings about the extragonadal suppression of various tissue regeneration-associated functions in endometrial stem cells, such as self-renewal, migration ability, multilineage differentiation potential, and pluripotency/stemness, by inhibiting pro-survival Akt and ERK1/2 signaling pathways in vitro and in vivo, and as a consequence, it decreases the endometrial receptivity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGERNATURE | - |
dc.relation.isPartOf | CELL DEATH & DISEASE | - |
dc.title | Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000824695400001 | - |
dc.identifier.doi | 10.1038/s41419-022-05054-7 | - |
dc.identifier.bibliographicCitation | CELL DEATH & DISEASE, v.13, no.7 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85133949726 | - |
dc.citation.title | CELL DEATH & DISEASE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Park, Se-Ra | - |
dc.contributor.affiliatedAuthor | Kim, Seong-Kwan | - |
dc.contributor.affiliatedAuthor | Kim, Soo-Rim | - |
dc.contributor.affiliatedAuthor | Lim, Soyi | - |
dc.contributor.affiliatedAuthor | Hong, In-Sun | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GENE-EXPRESSION OMNIBUS | - |
dc.subject.keywordPlus | OVARIAN STIMULATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PI3K/AKT | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | GONADOTROPIN | - |
dc.subject.keywordPlus | RECEPTIVITY | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | DISRUPTION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.