Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial
DC Field | Value | Language |
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dc.contributor.author | Nam, H.S. | - |
dc.contributor.author | Kim, Y.D. | - |
dc.contributor.author | Choi, J.K. | - |
dc.contributor.author | Baik, M. | - |
dc.contributor.author | Kim, B.M. | - |
dc.contributor.author | Kim, D.J. | - |
dc.contributor.author | Heo, J. | - |
dc.contributor.author | Shin, D.H. | - |
dc.contributor.author | Lee, K.-Y. | - |
dc.contributor.author | Jung, Y.H. | - |
dc.contributor.author | Baek, J.-H. | - |
dc.contributor.author | Hwang, Y.-H. | - |
dc.contributor.author | Sohn, S.-I. | - |
dc.contributor.author | Hong, J.-H. | - |
dc.contributor.author | Park, H. | - |
dc.contributor.author | Kim, C.K. | - |
dc.contributor.author | Kim, G.S. | - |
dc.contributor.author | Seo, K.-D. | - |
dc.contributor.author | Lee, K. | - |
dc.contributor.author | Seo, J.H. | - |
dc.contributor.author | Bang, O.Y. | - |
dc.contributor.author | Seo, W.-K. | - |
dc.contributor.author | Chung, J.-W. | - |
dc.contributor.author | Chang, J.Y. | - |
dc.contributor.author | Kwon, S.U. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Kim, J. | - |
dc.contributor.author | Yoo, J. | - |
dc.contributor.author | Song, T.-J. | - |
dc.contributor.author | Ahn, S.H. | - |
dc.contributor.author | Cho, B.-H. | - |
dc.contributor.author | Cho, H.-J. | - |
dc.contributor.author | Kim, J.G. | - |
dc.contributor.author | Chang, Y. | - |
dc.contributor.author | Lee, C.J. | - |
dc.contributor.author | Park, S. | - |
dc.contributor.author | Park, G. | - |
dc.contributor.author | Lee, H.S. | - |
dc.date.accessioned | 2022-09-22T23:40:03Z | - |
dc.date.available | 2022-09-22T23:40:03Z | - |
dc.date.created | 2021-09-07 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1747-4930 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85495 | - |
dc.description.abstract | Rationale: Very early stage blood pressure (BP) levels may affect outcome in stroke patients who have successfully undergone recanalization following intra-arterial treatment, but the optimal target of BP management remains uncertain. Aim: We hypothesized that the clinical outcome after intensive BP-lowering is superior to conventional BP control after successful recanalization by intra-arterial treatment. Sample-size estimates: We aim to randomize 668 patients (334 per arm), 1:1. Methods and design: We initiated a multicenter, prospective, randomized, open-label trial with a blinded end-point assessment (PROBE) design. After successful recanalization (thrombolysis in cerebral infarction score ≥ 2 b), patients with elevated systolic BP level, defined as the mean of two readings ≥ 140 mmHg, will be randomly assigned to the intensive BP-lowering (systolic BP < 140 mm Hg) group or the conventional BP-lowering (systolic BP, 140−180 mm Hg) group. Study outcomes: The primary efficacy outcomes are from dichotomized analysis of modified Rankin Scale (mRS) scores at three months (mRS scores: 0–2 vs. 3–6). The primary safety outcomes are symptomatic intracerebral hemorrhage and death within three months. Discussion: The OPTIMAL-BP trial will provide evidence for the effectiveness of active BP control to achieve systolic BP < 140 mmHg during 24 h in patients with successful recanalization after intra-arterial treatment. Clinical trial registration: ClinicalTrials.gov Identifier: NCT04205305. © 2021 World Stroke Organization. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE Publications Inc. | - |
dc.relation.isPartOf | International Journal of Stroke | - |
dc.title | Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000691037500001 | - |
dc.identifier.doi | 10.1177/17474930211041213 | - |
dc.identifier.bibliographicCitation | International Journal of Stroke, v.17, no.8, pp.931 - 937 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85113924080 | - |
dc.citation.endPage | 937 | - |
dc.citation.startPage | 931 | - |
dc.citation.title | International Journal of Stroke | - |
dc.citation.volume | 17 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Shin, D.H. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | blood pressure | - |
dc.subject.keywordAuthor | cerebral infarction | - |
dc.subject.keywordAuthor | outcome research | - |
dc.subject.keywordAuthor | Reperfusion therapy | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | RECANALIZATION | - |
dc.subject.keywordPlus | THROMBOLYSIS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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