RHOA protein expression correlates with clinical features in gastric cancer: a systematic review and meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Seungyoon | - |
dc.contributor.author | Lee, Yeeun | - |
dc.contributor.author | Kim, Jung Ho | - |
dc.date.accessioned | 2022-09-23T23:40:06Z | - |
dc.date.available | 2022-09-23T23:40:06Z | - |
dc.date.created | 2022-09-22 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85504 | - |
dc.description.abstract | Background Gastric cancer (GC) is one of the most fatal cancers worldwide and is generally only detected after it has progressed to an advanced stage. Since there is a lack of comprehensive data on RHOA protein expression of patients with GC, this study utilized a systematic review and meta-analysis to address the limitation. The objective of this meta-analysis was to link GC clinical features with RHOA protein high- vs. low-expressing patients with GC. Methods The PubMed and Web of Science were used for a systematic literature review of GC related to RHOA. The included studies were obtained from two literature databases from past to Aug 31, 2021, by searching keywords. This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The odds ratios (ORs) and 95% confidential intervals (CIs) for clinical features were estimated according to the high and low protein expression levels of RhoA. The mean effect sizes of ORs were obtained using the random-effects and fixed-effects models of meta-analysis. Heterogeneity of the studies was assesed by using statistics: tau(2), I-2; and Q values. The symmetry of funnel plots were inspected for publication bias. Results Finally, 10 studies including 1,389 patients with GC (735 RHOA-positive and 654 RHOA-negative) were eligible for our meta-analysis to estimate associations between the protein expression and clinical features (e.g., Union for International Cancer Control [UICC] stage progression, differentiation, Lauren histological classification, and vascular invasion). In our meta-analysis, RHOA positive expression was determined to have a statistically significant association with UICC stage progression (P = 0.02) and poorly differentiated status (P = 0.02). The association between RHOA positivity and Lauren subtypes was not statistically significant (P = 0.07). Conclusions This meta-analysis suggested that RhoA protein expression in patients with GC was associated with clinical features: UICC stage progression and poorly differentiated status. Our findings are inconclusive but indicate that high RHOA protein expressing patients with GC could predict advanced UICC stages. A large prospective cohort study is required for validation in future. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.title | RHOA protein expression correlates with clinical features in gastric cancer: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000827751100007 | - |
dc.identifier.doi | 10.1186/s12885-022-09904-7 | - |
dc.identifier.bibliographicCitation | BMC CANCER, v.22, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85134407903 | - |
dc.citation.title | BMC CANCER | - |
dc.citation.volume | 22 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Nam, Seungyoon | - |
dc.contributor.affiliatedAuthor | Lee, Yeeun | - |
dc.contributor.affiliatedAuthor | Kim, Jung Ho | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | RHOA | - |
dc.subject.keywordAuthor | Gastric cancer | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
dc.subject.keywordPlus | SPINAL-CORD-INJURY | - |
dc.subject.keywordPlus | DIFFUSE-TYPE | - |
dc.subject.keywordPlus | CHEMOTHERAPY RESISTANCE | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | INVASION | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.