Low Klotho/Fibroblast Growth Factor 23 Ratio Is an Independent Risk Factor for Renal Progression in Chronic Kidney Disease: Finding From KNOW-CKD
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyo Jin | - |
dc.contributor.author | Kim, Yunmi | - |
dc.contributor.author | Kang, Minjung | - |
dc.contributor.author | Kim, Seonmi | - |
dc.contributor.author | Park, Sue Kyung | - |
dc.contributor.author | Sung, Suah | - |
dc.contributor.author | Hyun, Young Youl | - |
dc.contributor.author | Jung, Ji Yong | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.date.accessioned | 2022-09-27T02:40:08Z | - |
dc.date.available | 2022-09-27T02:40:08Z | - |
dc.date.created | 2022-09-22 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 2296-858X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85522 | - |
dc.description.abstract | BackgroundWe aimed to evaluate soluble Klotho and circulating fibroblast growth factor 23 (FGF23) ratio as a risk factor for renal progression, cardiovascular (CV) events, and mortality in chronic kidney disease (CKD). MethodsWe analyzed 2,099 subjects from a CKD cohort whose soluble Klotho and C-terminal FGF23 levels were measured at enrollment. The Klotho to FGF23 ratio was calculated as Klotho values divided by FGF23 values + 1 (hereinafter called the Klotho/FGF23 ratio). Participants were categorized into quartiles according to Klotho/FGF23 ratio. The primary outcome was renal events, defined as the doubling of serum creatinine, 50% reduction of estimated glomerular filtration rate from the baseline values, or development of end-stage kidney disease. The secondary outcomes consisted of CV events and death. Changes in CV parameters at the time of enrollment and during follow-up according to the Klotho/FGF23 ratio were also examined. ResultsDuring the follow-up period of 64.0 +/- 28.2 months, 735 (35.1%) and 273 (13.0%) subjects developed renal events and composite outcomes of CV events and death, respectively. After adjustment, the first (HR: 1.36; 95% CI: 1.08-1.72, P = 0.010) and second (HR: 1.45; 95% CI: 1.15-1.83, P = 0.002) quartiles with regard to the Klotho/FGF23 ratio showed elevated risk of renal events as compared to the fourth quartile group. There was no significant association between Klotho/FGF23 ratio and the composite outcome of CV events and death. The prevalence of left ventricular hypertrophy and vascular calcification was higher in the low Klotho/FGF23 ratio quartiles at baseline and at the fourth-year follow-up. ConclusionsLow Klotho/FGF23 ratio was significantly associated with increased renal events in the cohort of Korean predialysis CKD patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN MEDICINE | - |
dc.title | Low Klotho/Fibroblast Growth Factor 23 Ratio Is an Independent Risk Factor for Renal Progression in Chronic Kidney Disease: Finding From KNOW-CKD | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000830185600001 | - |
dc.identifier.doi | 10.3389/fmed.2022.904963 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN MEDICINE, v.9 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85134607418 | - |
dc.citation.title | FRONTIERS IN MEDICINE | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Jung, Ji Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Klotho | - |
dc.subject.keywordAuthor | fibroblast growth factor 23 | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | renal progression | - |
dc.subject.keywordAuthor | mortality | - |
dc.subject.keywordPlus | SOLUBLE KLOTHO | - |
dc.subject.keywordPlus | PHYSICAL-ACTIVITY | - |
dc.subject.keywordPlus | FGF23 | - |
dc.subject.keywordPlus | FGF-23 | - |
dc.subject.keywordPlus | CALCIFICATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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