Inhibition of A2780 Human Ovarian Carcinoma Cell Proliferation by a Rubus Component, Sanguiin H-6
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Ko, Hyeonseok | - |
dc.contributor.author | Kim, Young-Joo | - |
dc.contributor.author | Kim, Su-Nam | - |
dc.contributor.author | Choi, Kyung-Chul | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Shibamoto, Takayuki | - |
dc.date.available | 2020-02-28T02:45:06Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-02-03 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8552 | - |
dc.description.abstract | The effects of a red raspberry component, sanguiin H-6 (SH-6), on the induction of apoptosis and the related signaling pathways in A2780 human ovarian carcinoma cells were investigated. SH-6 caused an antiproliferative effect and a severe morphological change resembling that of apoptotic cell death but no effect on the cancer cell cycle arrest: In addition, SH-6 induced an early apoptotic effect and activation of caspases as well as the deavage of PARP, which is a hallmark of apoptosis. The early apoptotic percentages of A2780 cells exposed to 20 and 40 mu M SH-6 were 35.39 and 41.76, respectively. Also, SH-6 caused the activation of mitogen-activated protein, kinases (MAPKs), especially p38, and the increase of truncated p15/BID. These results in the present study suggest that the apoptosis of A2780 human ovarian carcinoma cells by SH-6 is mediated by the MAPK p38 and a caspase-8-dependent BID cleavage pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.subject | CANCER | - |
dc.subject | RESISTANCE | - |
dc.subject | APOPTOSIS | - |
dc.subject | PHENOLICS | - |
dc.title | Inhibition of A2780 Human Ovarian Carcinoma Cell Proliferation by a Rubus Component, Sanguiin H-6 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000369557200009 | - |
dc.identifier.doi | 10.1021/acs.jafc.5b05461 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.64, no.4, pp.801 - 805 | - |
dc.identifier.scopusid | 2-s2.0-84956962687 | - |
dc.citation.endPage | 805 | - |
dc.citation.startPage | 801 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Yamabe, Noriko | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | A2780 ovarian carcinoma cells | - |
dc.subject.keywordAuthor | caspase | - |
dc.subject.keywordAuthor | MAPK p38 | - |
dc.subject.keywordAuthor | polyphenols | - |
dc.subject.keywordAuthor | raspberry | - |
dc.subject.keywordAuthor | sanguiin H-6 | - |
dc.subject.keywordAuthor | truncated BID | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PHENOLICS | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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