The Ameliorating Effect of Lizhong-Tang on Antibiotic-Associated Imbalance in the Gut Microbiota in Mouse
DC Field | Value | Language |
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dc.contributor.author | Ahn, Hye-Ri | - |
dc.contributor.author | Park, Do Hwi | - |
dc.contributor.author | Shin, Myoung-Sook | - |
dc.contributor.author | Nguyen, Quynh Nhu | - |
dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Kim, Dong-Wook | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Lee, Hye Lim | - |
dc.date.accessioned | 2022-09-27T02:40:21Z | - |
dc.date.available | 2022-09-27T02:40:21Z | - |
dc.date.created | 2022-09-22 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85537 | - |
dc.description.abstract | Some herbal medicines have anti-inflammatory and anti-diarrheal effects. This study analyzed the modulating effect of gut microbiota of anti-inflammatory herbal medicines on antibiotic-associated diarrhea (AAD). The anti-inflammatory effects of 10 herbal medicines and Lizhong-tang active compounds were studied by measuring the nitric oxide production in an in vitro experiment. This was followed by an in vivo experiment in which the anti-diarrheal effects of Lizhong-tang and Magnolia officinalis in a lincomycin-induced AAD mouse model were measured. Changes in the intestinal microflora were observed using terminal restriction fragment length polymorphism analysis. Both Lizhong-tang and M. officinalis were effective against AAD, with Lizhong-tang's anti-diarrheal effects being particularly effective. In addition, the active compounds of Lizhong-tang, liquiritin and 6-gingerol, inhibited the expression of inducible nitric oxide synthase and cyclooxygenase-2, thus showing an anti-inflammatory effect. Gut microbiota analysis showed that Lizhong-tang could alter the composition of the gut microbiota and ameliorated imbalance in the gut microbiota in a lincomycin-induced AAD mouse model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | APPLIED SCIENCES-BASEL | - |
dc.title | The Ameliorating Effect of Lizhong-Tang on Antibiotic-Associated Imbalance in the Gut Microbiota in Mouse | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000833681100001 | - |
dc.identifier.doi | 10.3390/app12146943 | - |
dc.identifier.bibliographicCitation | APPLIED SCIENCES-BASEL, v.12, no.14 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85137330343 | - |
dc.citation.title | APPLIED SCIENCES-BASEL | - |
dc.citation.volume | 12 | - |
dc.citation.number | 14 | - |
dc.contributor.affiliatedAuthor | Park, Do Hwi | - |
dc.contributor.affiliatedAuthor | Shin, Myoung-Sook | - |
dc.contributor.affiliatedAuthor | Nguyen, Quynh Nhu | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | herbal medicine | - |
dc.subject.keywordAuthor | Lizhong-tang | - |
dc.subject.keywordAuthor | gut microbiota | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | PROBIOTICS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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