Inhibitory effect of 20(S)-protopanaxadiol on cytochrome P450: Potential of its pharmacokinetic interactions in vivo
DC Field | Value | Language |
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dc.contributor.author | Lee, Su Gwon | - |
dc.contributor.author | Cho, Kwan Hyung | - |
dc.contributor.author | Nguyen, Thi-Thao-Linh | - |
dc.contributor.author | Vo, Dang-Khoa | - |
dc.contributor.author | Chae, Yoon-Jee | - |
dc.contributor.author | Maeng, Han-Joo | - |
dc.date.accessioned | 2022-09-27T06:40:13Z | - |
dc.date.available | 2022-09-27T06:40:13Z | - |
dc.date.created | 2022-09-22 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85554 | - |
dc.description.abstract | 20(S)-Protopanaxadiol [20(S)-PPD] is a fully deglycosylated ginsenoside metabolite produced by the gut microbiota in the gastrointestinal tract. Although diverse pharmacological effects have been reported, infor-mation on the pharmacokinetic interactions of 20(S)-PPD with cytochrome P450s (CYPs) remains limited. Therefore, the inhibitory potential of 20(S)-PPD on CYP enzymes, which mainly contribute to drug pharmaco-kinetics, was investigated in this study. The inhibitory effect of 20(S)-PPD was strong for CYP3A4 and moderate for CYP2B6 in human liver microsomes. 20(S)-PPD inhibited Cyp3a and Cyp2b in mouse liver microsomes with a potency similar to that in humans. The solubility of 20(S)-PPD in the artificial intestinal fluid was close to IC50 values of Cyp3a and Cyp2b in the mouse intestine. Systemic exposure to buspirone (Cyp3a specific substrate) and bupropion (Cyp2b specific substrate) increased significantly, whereas the area under the plasma concen-tration-time curve (AUC) ratio of metabolite to parent drug decreased significantly when co-administered with 20(S)-PPD in mice. The pharmacokinetics of felodipine, a widely used anti-hypertensive agent metabolized mainly by Cyp3a, was also altered following 20(S)-PPD treatment in mice. In conclusion, 20(S)-PPD likely affects the in vivo metabolism of CYP3A4 or CYP2B6 substrates, suggesting a need for careful attention when concomitantly administering 20(S)-PPD with other medications. This study will broaden our understanding of ginseng and products containing precursor ginsenosides of 20(S)-PPD for safer and more efficient use in humans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.relation.isPartOf | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.title | Inhibitory effect of 20(S)-protopanaxadiol on cytochrome P450: Potential of its pharmacokinetic interactions in vivo | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000838929500007 | - |
dc.identifier.doi | 10.1016/j.biopha.2022.113514 | - |
dc.identifier.bibliographicCitation | BIOMEDICINE & PHARMACOTHERAPY, v.153 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85136093806 | - |
dc.citation.title | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.volume | 153 | - |
dc.contributor.affiliatedAuthor | Lee, Su Gwon | - |
dc.contributor.affiliatedAuthor | Nguyen, Thi-Thao-Linh | - |
dc.contributor.affiliatedAuthor | Vo, Dang-Khoa | - |
dc.contributor.affiliatedAuthor | Maeng, Han-Joo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 20(S)-protopanaxadiol | - |
dc.subject.keywordAuthor | Cytochrome P450 (CYP) | - |
dc.subject.keywordAuthor | Drug interactions | - |
dc.subject.keywordAuthor | Drug metabolism | - |
dc.subject.keywordAuthor | Ginsenoside | - |
dc.subject.keywordPlus | MECHANISM-BASED INHIBITION | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | RED GINSENG | - |
dc.subject.keywordPlus | DRUG-INTERACTIONS | - |
dc.subject.keywordPlus | HUMAN CYP2B6 | - |
dc.subject.keywordPlus | GINSENOSIDES | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYP2C19 | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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