Total Synthesis of Isohericerinol A and Its Analogues to Access Their Potential Neurotrophic Effects
DC Field | Value | Language |
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dc.contributor.author | Vishwanath, Manjunatha | - |
dc.contributor.author | Chaudhary, Chhabi Lal | - |
dc.contributor.author | Park, Yunjeong | - |
dc.contributor.author | Viji, Mayavan | - |
dc.contributor.author | Jung, Chanhyun | - |
dc.contributor.author | Lee, Kwanghee | - |
dc.contributor.author | Sim, Jaeuk | - |
dc.contributor.author | Hong, Seong Min | - |
dc.contributor.author | Yoon, Da Hye | - |
dc.contributor.author | Lee, Dae Hee | - |
dc.contributor.author | Lee, Jae Kang | - |
dc.contributor.author | Lee, Heesoon | - |
dc.contributor.author | Lee, Mi Kyeong | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Jung, Jae-Kyung | - |
dc.date.accessioned | 2022-09-27T06:40:24Z | - |
dc.date.available | 2022-09-27T06:40:24Z | - |
dc.date.created | 2022-09-22 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85566 | - |
dc.description.abstract | The secondary metabolites from Hericium erinaceus are well-known to have neurotrophic and neuroprotective effects. Isohericerinol A (1), isolated by our colleagues from its fruiting parts has a strong ability to increase the nerve growth factor secretion in C6 glioma cells. The current work describes the total synthesis of 1 and its regioisomer 5 in a few steps. We present two different approaches to 1 and a regiodivergent approach for both 1 and 5 by utilizing easily accessible feedstocks. Interestingly, the natural product 1, regioisomer 5, and their intermediates exhibited potent neurotrophic activity in in vitro experimental systems. Thus, these synthetic strategies provide access to a systematic structure-activity relationship study of natural product 1. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF ORGANIC CHEMISTRY | - |
dc.title | Total Synthesis of Isohericerinol A and Its Analogues to Access Their Potential Neurotrophic Effects | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000842983200001 | - |
dc.identifier.doi | 10.1021/acs.joc.2c01096 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ORGANIC CHEMISTRY, v.87, no.16, pp.10836 - 10847 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85136282209 | - |
dc.citation.endPage | 10847 | - |
dc.citation.startPage | 10836 | - |
dc.citation.title | JOURNAL OF ORGANIC CHEMISTRY | - |
dc.citation.volume | 87 | - |
dc.citation.number | 16 | - |
dc.contributor.affiliatedAuthor | Hong, Seong Min | - |
dc.contributor.affiliatedAuthor | Yoon, Da Hye | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | LIONS MANE MUSHROOM | - |
dc.subject.keywordPlus | HERICIUM-ERINACEUS | - |
dc.subject.keywordPlus | FRUITING BODIES | - |
dc.subject.keywordPlus | MEDICINAL MUSHROOMS | - |
dc.subject.keywordPlus | AROMATIC-COMPOUNDS | - |
dc.subject.keywordPlus | NERVE GROWTH | - |
dc.subject.keywordPlus | C-H | - |
dc.subject.keywordPlus | HERICENONES | - |
dc.subject.keywordPlus | MYCELIA | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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