Effectiveness and Safety of Codeine and Levodropropizine in Patients With Chronic Cough
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sang Pyo | - |
dc.contributor.author | Lee, Sang Min | - |
dc.contributor.author | Lee, Byung-Jae | - |
dc.contributor.author | Kang, Sung-Yoon | - |
dc.date.accessioned | 2022-10-06T01:40:09Z | - |
dc.date.available | 2022-10-06T01:40:09Z | - |
dc.date.created | 2022-09-20 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85616 | - |
dc.description.abstract | Background: Recent progress in chronic cough management includes controlling cough triggers and hypersensitivity using antitussives. Therefore, we investigated the effects and safety outcomes of antitussives, codeine and levodropropizine, in patients with chronic cough. Methods: We conducted an open-label, randomized comparative trial with newly referred patients with chronic cough. Patients were orally administered codeine (60 mg/day) and levodropropizine (180 mg/day) for 2 weeks. Cough severity, including the visual analog scale (VAS), Cough Symptom Score (CSS), Leicester Cough Questionnaire (LCQ), and safety for each treatment were assessed. The primary outcome was VAS score changes before and after 2 weeks of treatment. Results: Among the 88 participants, 45 and 43 in the codeine and levodropropizine groups, respectively, were included in the analysis. Changes in the VAS score were higher in the codeine group than in the levodropropizine group (35.11 ± 20.74 vs. 19.77 ± 24.83, P = 0.002). Patients administered codeine also had improved CSS (2.96 ± 2.35 vs. 1.26 ± 1.89, P < 0.001) and LCQ (3.28 ± 3.36 vs. 1.61 ± 3.53, P = 0.025) than those administered levodropropizine. Treatment-related adverse events, including drowsiness, constipation, and headaches, were more frequent in the codeine group than in the levodropropizine group. However, no significant differences existed in the adverse events leading to discontinuation. Conclusion: Codeine is an effective and generally well-tolerated antitussive for chronic cough. However, it may induce side effects in some patients. Individual responses and adverse events should be carefully monitored when codeine is used to treat chronic cough. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한의학회 | - |
dc.relation.isPartOf | Journal of Korean Medical Science | - |
dc.title | Effectiveness and Safety of Codeine and Levodropropizine in Patients With Chronic Cough | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000859314500001 | - |
dc.identifier.doi | 10.3346/jkms.2022.37.e275 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.37, no.36, pp.1 - 11 | - |
dc.identifier.kciid | ART002876941 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85138202226 | - |
dc.citation.endPage | 11 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 37 | - |
dc.citation.number | 36 | - |
dc.contributor.affiliatedAuthor | Lee, Sang Pyo | - |
dc.contributor.affiliatedAuthor | Lee, Sang Min | - |
dc.contributor.affiliatedAuthor | Kang, Sung-Yoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Chronic Cough | - |
dc.subject.keywordAuthor | Codeine | - |
dc.subject.keywordAuthor | Levodropropizine Visual Analogue Scale | - |
dc.subject.keywordAuthor | Safety | - |
dc.subject.keywordPlus | EXHALED NITRIC-OXIDE | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | RELEVANCE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | VALIDITY | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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